International Journal of Biochemistry and Cell Biology 100 (2018) 11–21 Contents lists available at ScienceDirect International Journal of Biochemistry and Cell Biology journal homepage: www.elsevier.com/locate/biocel Time-course expression proﬁle and diagnostic potential of a miRNA panel in exosomes and total serum in acute liver injury a b a b Tarek K. Motawi , Mohamed R. Mohamed , Nancy N. Shahin , Mohamed A.M. Ali , a, May A. Azzam Biochemistry Department, Faculty of Pharmacy, Cairo University, Egypt Biochemistry Department, Faculty of Science, Ain Shams University, Egypt ARTIC L E I NF O ABSTRAC T Keywords: Circulating miRNAs have recently emerged as attractive candidates for biomarker discovery. However, they Drug-induced liver injury have a variant distribution in circulation, and the diagnostic signiﬁcance of their compartmentalization is yet to Acetaminophen be elucidated. This study explored the time-course expression proﬁle and the diagnostic potential of miRNAs- Thioacetamide 122a-5p, 192-5p, 193a-3p and 194-5p in exosomal and total serum compartments in two rat models of acute Extracellular vesicles liver injury (ALI) . Exosomes were isolated and characterized in terms of morphology, size and CD-63 surface Biomarkers marker expression. Exosomal, serum and hepatic miRNAs were quantiﬁed using q-RT-PCR. An inverse expres- sion pattern of hepatic and
The International Journal of Biochemistry & Cell Biology – Elsevier
Published: Jul 1, 2018
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