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derivatives by inhibiting specific cancer biological targets , such as inhibiting telomerase activity, HDAC, thymidylate synthase, and the thymidine phosphorylase enzyme. The purpose of this review ...
), and the fractional retention of thymidine (FRT). Changes in PET parameters between scans in the AG337- treated and control groups were compared using the Mann–Whitney U test. The relationship between AG337 exposure ...
Abstract Capecitabine is a thymidine phosphorylase (TP)-activated oral fluoropyrimidine, rationally designed to generate 5-fluorouracil (5-FU) preferentially within tumors. This tumor selectivity ...
to assess the potential of new drugs. Long-term end-points such as survival or time to progression are needed in phase III trials of cytotoxic drugs and molecularly targeted agents to fully evaluate response ...
that angiogenesis can be a potential therapeutic target in breast cancer. Bevacizumab has been tested in a phase II trial in patients with previously treated metastatic breast cancer [37]. Among the 75 patients ...
antineoplastic agent consisting of trifluridine (a trifluorothymidine, a thymidine -based nucleoside analog) and tipiracil (a thymidine phosphorylase inhibitor), at a molar ratio of 1:0.5. Tipiracil blocks ...
Abstract Objectives: Gliostatin (GLS) has angiogenic and arthritogenic activities and enzymatic activity as thymidine phosphorylase . Aberrant GLS production has been observed in the synovial ...
) Proliferation of PF-382, JVM-2 and HT-29 cell lines treated with different doses of MTX for 96h in presence or absence of Hypoxanthine- Thymidine . Data represent mean ± standard deviation of four experiments. c ...
of determining endogenous purine and pyrimidine previously established in the laboratory, a targeted metabolomic analysis of TP was carried out. Finally, six nephrotoxicity biomarkers, dihydroorotate, thymidine , 2 ...
]. At least two mechanisms are likely to contribute to the efficacy of capecitabine and to its potential utility in combination therapy. First, thymidine phosphorylase , the final enzyme in the conversion ...
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