Thymidine phosphorylase: A potential new target for treating cardiovascular disease

Thymidine phosphorylase: A potential new target for treating cardiovascular disease We recently found that thymidine phosphorylase (TYMP), also known as platelet-derived endothelial cell growth factor, plays an important role in platelet activation in vitro and thrombosis in vivo by participating in multiple signaling pathways. Platelets are a major source of TYMP. Since platelet-mediated clot formation is a key event in several fatal diseases, such as myocardial infarction, stroke and pulmonary embolism, understanding TYMP in depth may lead to uncovering novel mechanisms in the development of cardiovascular diseases. Targeting TYMP may become a novel therapeutic for cardiovascular disorders. In this review article, we summarize the discovery of TYMP and the potential molecular mechanisms of TYMP involved in the development of various diseases, especially cardiovascular diseases. We also offer insights regarding future studies exploring the role of TYMP in the development of cardiovascular disease as well as in therapy. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Trends in Cardiovascular Medicine Elsevier

Thymidine phosphorylase: A potential new target for treating cardiovascular disease

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier Inc.
ISSN
1050-1738
D.O.I.
10.1016/j.tcm.2017.10.003
Publisher site
See Article on Publisher Site

Abstract

We recently found that thymidine phosphorylase (TYMP), also known as platelet-derived endothelial cell growth factor, plays an important role in platelet activation in vitro and thrombosis in vivo by participating in multiple signaling pathways. Platelets are a major source of TYMP. Since platelet-mediated clot formation is a key event in several fatal diseases, such as myocardial infarction, stroke and pulmonary embolism, understanding TYMP in depth may lead to uncovering novel mechanisms in the development of cardiovascular diseases. Targeting TYMP may become a novel therapeutic for cardiovascular disorders. In this review article, we summarize the discovery of TYMP and the potential molecular mechanisms of TYMP involved in the development of various diseases, especially cardiovascular diseases. We also offer insights regarding future studies exploring the role of TYMP in the development of cardiovascular disease as well as in therapy.

Journal

Trends in Cardiovascular MedicineElsevier

Published: Apr 1, 2018

References

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