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The three ‐ dimensional structure of notexin has been solved by molecular replacement methods. The structure has been refined at 2.0 Å resolution to a crystallographic R‐value of 16.5% with good stereo ...
. multicinctus, respectively. Although they share a common three ‐ dimensional structure , the functional elements essential for the manifestation of their toxicity are different. Selective and stepwise chemical ...
The three - dimensional structure of the highly toxic crotoxin from Crotalus durissus terrificus was modelled based on sequence analysis and the refined structure of calcium-free phospholipase ...
in the brain may drive early pathogenic effects, while Lewy body-associated α-synuclein can drive neurotoxicity . Graphical Abstract Open in new tabDownload slide Graphical Abstract Open in new tabDownload slide ...
to yield the mature protein. (B) (Left) Three - dimensional structure of α-latrotoxin, and (right) homotetramer indicating position of the protein domains determined from cryo-EM microscopy (modified from ...
alterations in this circuit, we used focused ion beam milling/scanning electron microscopy to reveal and quantify the three - dimensional synaptic organization of the neuropil of the stratum radiatum of the rat ...
, that help distinguish odorous from odorless molecules, including electrophilicity and structure linearity. Applying our current model to the GDB17, a database of all possible molecules with 17 or fewer heavy ...
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