Therapeutic potential of spinal GLP-1 receptor signaling

Therapeutic potential of spinal GLP-1 receptor signaling •We summarized the expression of GLP-1R and the innervation of PPG neurons in the spinal cord.•Stimulation of GLP-1R within the spinal cord promotes neuroprotection in specific neurodegenerative and traumatic spinal cord disorders.•Activating GLP-1R in spinal microglia cells suppresses nociceptive sensitization. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Peptides Elsevier

Therapeutic potential of spinal GLP-1 receptor signaling

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier Inc.
ISSN
0196-9781
D.O.I.
10.1016/j.peptides.2018.01.003
Publisher site
See Article on Publisher Site

Abstract

•We summarized the expression of GLP-1R and the innervation of PPG neurons in the spinal cord.•Stimulation of GLP-1R within the spinal cord promotes neuroprotection in specific neurodegenerative and traumatic spinal cord disorders.•Activating GLP-1R in spinal microglia cells suppresses nociceptive sensitization.

Journal

PeptidesElsevier

Published: Mar 1, 2018

References

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