The Zebrafish trilobite Gene Is Essential for Tangential Migration of Branchiomotor Neurons

The Zebrafish trilobite Gene Is Essential for Tangential Migration of Branchiomotor Neurons Newborn neurons migrate extensively in the radial and tangential directions to organize the developing vertebrate nervous system. We show here that mutations in zebrafish trilobite ( tri ) that affect gastrulation-associated cell movements also eliminate tangential migration of motor neurons in the hindbrain. In the wild-type hindbrain, facial (nVII) and glossopharyngeal (nIX) motor neurons are induced in rhombomeres 4 and 6, respectively, and migrate tangentially into r6 and r7 (nVII) and r7 (nIX). In all three tri alleles examined, although normal numbers of motor neurons are induced, nVII motor neurons are found exclusively in r4, and nIX-like motor neurons are found exclusively in r6. The migration of other neuronal and nonneuronal cell types is unaffected in tri mutants. Rhombomere formation and the development of other hindbrain neurons are also unaffected in tri mutants. Furthermore, tangential neuronal migration occurs normally in the gastrulation mutant knypek , indicating that the trilobite neuron phenotype does not arise nonspecifically from aberrant gastrulation-associated movements. We conclude that trilobite function is specifically required for two types of cell migration that occur at different stages of zebrafish development. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Developmental Biology Elsevier

The Zebrafish trilobite Gene Is Essential for Tangential Migration of Branchiomotor Neurons

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Publisher
Elsevier
Copyright
Copyright © 2001 Elsevier Science (USA)
ISSN
0012-1606
eISSN
1095-564X
D.O.I.
10.1006/dbio.2001.0532
Publisher site
See Article on Publisher Site

Abstract

Newborn neurons migrate extensively in the radial and tangential directions to organize the developing vertebrate nervous system. We show here that mutations in zebrafish trilobite ( tri ) that affect gastrulation-associated cell movements also eliminate tangential migration of motor neurons in the hindbrain. In the wild-type hindbrain, facial (nVII) and glossopharyngeal (nIX) motor neurons are induced in rhombomeres 4 and 6, respectively, and migrate tangentially into r6 and r7 (nVII) and r7 (nIX). In all three tri alleles examined, although normal numbers of motor neurons are induced, nVII motor neurons are found exclusively in r4, and nIX-like motor neurons are found exclusively in r6. The migration of other neuronal and nonneuronal cell types is unaffected in tri mutants. Rhombomere formation and the development of other hindbrain neurons are also unaffected in tri mutants. Furthermore, tangential neuronal migration occurs normally in the gastrulation mutant knypek , indicating that the trilobite neuron phenotype does not arise nonspecifically from aberrant gastrulation-associated movements. We conclude that trilobite function is specifically required for two types of cell migration that occur at different stages of zebrafish development.

Journal

Developmental BiologyElsevier

Published: Feb 15, 2002

References

  • Neuronal migration disorders in humans and in mouse models: An overview
    Copp, A.J.; Harding, B.N.
  • Central nervous system neuronal migration
    Hatten, M.E.
  • Stages of embryonic development of the zebrafish
    Kimmel, C.B.; Ballard, W.W.; Kimmel, S.R.; Ullmann, B.; Schilling, T.F.
  • Functional interactions of genes mediating convergent extension, knypek and trilobite , during the partitioning of the eye primordium in zebrafish
    Marlow, F.; Zwartkruis, F.; Malicki, J.; Neuhauss, S.C.; Abbas, L.; Weaver, M.; Driever, W.; Solnica-Krezel, L.
  • New directions for neuronal migration
    Pearlman, A.L.; Faust, P.L.; Hatten, M.E.; Brunstrom, J.E.

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