The type II peroxiredoxin gene family of the mouse: molecular structure, expression and evolution 1 The nucleotide sequence data reported in this paper have been submitted to GenBank and assigned the Accession Nos AF032714 through AF032722. 1

The type II peroxiredoxin gene family of the mouse: molecular structure, expression and evolution... Peroxiredoxins (Prxs) are a newly defined family of antioxidant proteins that have been implicated, via their antioxidant activity, in a number of cellular functions, including cell proliferation and differentiation, protection of other proteins from oxidative damage, and intracellular signaling. We isolated genomic DNA sequences of the type II Prx ( Prx II ) gene from the mouse and analyzed their molecular genetic characteristics. In the mouse, the Prx II is found to form a small multigene family with three members. One of them, the Prx II-1 gene, is actively transcribed in a variety of adult tissues as well as in the developing embryos to produce a 1.1-kb mRNA. The Prx II-1 gene consists of six exons and five introns, and the whole transcription unit occupies about 4.5 kb in the mouse genome. The other two genes, Prx II-2 and Prx II-3 , are encoded by single exons, and show 97.5 and 87% of nucleotide sequence homology with the Prx II-1 gene, respectively. Structural features of these genes and the results of RT-PCR analysis on RNAs from various tissue sources indicate that the Prx II-2 and Prx II-3 genes could be pseudogenes derived from the Prx II-1 gene by a mechanism involving retrotransposition. These results strongly suggest that only the Prx II-1 gene might be relevant for studying the function of the Prx II gene in the murine system. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Gene Elsevier

The type II peroxiredoxin gene family of the mouse: molecular structure, expression and evolution 1 The nucleotide sequence data reported in this paper have been submitted to GenBank and assigned the Accession Nos AF032714 through AF032722. 1

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Publisher
Elsevier
Copyright
Copyright © 1998 Elsevier Science B.V.
ISSN
0378-1119
eISSN
1879-0038
D.O.I.
10.1016/S0378-1119(98)00290-X
Publisher site
See Article on Publisher Site

Abstract

Peroxiredoxins (Prxs) are a newly defined family of antioxidant proteins that have been implicated, via their antioxidant activity, in a number of cellular functions, including cell proliferation and differentiation, protection of other proteins from oxidative damage, and intracellular signaling. We isolated genomic DNA sequences of the type II Prx ( Prx II ) gene from the mouse and analyzed their molecular genetic characteristics. In the mouse, the Prx II is found to form a small multigene family with three members. One of them, the Prx II-1 gene, is actively transcribed in a variety of adult tissues as well as in the developing embryos to produce a 1.1-kb mRNA. The Prx II-1 gene consists of six exons and five introns, and the whole transcription unit occupies about 4.5 kb in the mouse genome. The other two genes, Prx II-2 and Prx II-3 , are encoded by single exons, and show 97.5 and 87% of nucleotide sequence homology with the Prx II-1 gene, respectively. Structural features of these genes and the results of RT-PCR analysis on RNAs from various tissue sources indicate that the Prx II-2 and Prx II-3 genes could be pseudogenes derived from the Prx II-1 gene by a mechanism involving retrotransposition. These results strongly suggest that only the Prx II-1 gene might be relevant for studying the function of the Prx II gene in the murine system.

Journal

GeneElsevier

Published: Aug 17, 1998

References

  • Hydroperoxide metabolism in mammalian organs
    Chance, B.; Sies, H.; Boveris, A.
  • Inhibition of the thiol-specific antioxidant activity of rat liver MSP23 protein by hemin
    Ishii, T.; Kawane, T.; Taketani, S.; Bannai, S.
  • Antioxidant function of recombinant human natural killer enhancing factor
    Sauri, H.; Butterfield, L.; Kim, A.; Shau, H.
  • Possible function of SP-22, a substrate of mitochondrial ATP-dependent protease, as a radical scavenger
    Watabe, S.; Hasegawa, H.; Takimoto, K.; Yamamoto, Y.; Takahashi, S.Y.

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