Alberta Azzi, Massirno Morfini and Pier Mannuccio Mannucci HE HUMAN PARVOVIRUS B19 is a member of the family Parvoviridae (subfamily: Parvovirinae) that recently, because of its tropism for red blood cell progenitors, has been placed in the genus Erythrovirus. 1 Most parr are common animal pathogens, such as feline panleukopenia parvovirus and canine parvovirus. However, animal parvoviruses are not transmissible to humans and parvovirus B19 is the only known human-pathogenic parvovirus. 2 B 19 virus was discovered by chance by Y.E. Cossart and her associates 3 in 1975, while screening plasma of blood donors for hepatitis B antigen. It was first named "serum parvovirus-like virus" and then human parvovirus B 19, from the number of plasma samples in which it was found for the first time) The virus was independently described also in France and Japan, where it was called Auriltac or Nakatani antigen, respectively. Thus, B 19 virus was initially detected in asymptomatic individuals, and asymptomatic B19 infections occurs in 20% to 30% of individuals: It took several years to prove the causative role of B 19 virus in human diseases. Now B19 virus is known to be responsible for a variety of clinical manifestations, which depend
Transfusion Medicine Reviews – Elsevier
Published: Jul 1, 1999
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