The selective neurokinin (NK) 1 antagonist, GR205,171, stereospecifically enhances mesocortical dopaminergic transmission in the rat: a combined dialysis and electrophysiological study

The selective neurokinin (NK) 1 antagonist, GR205,171, stereospecifically enhances mesocortical... Upon acute, systemic administration, the selective, non-peptidergic NK 1 receptor antagonist, GR205,171, dose-dependently enhanced the firing rate of ventrotegmental dopaminergic neurones. Dialysate levels of dopamine were increased in the frontal cortex, but not in the striatum and nucleus accumbens, of conscious rats. These actions were stereospecific in that its less-active isomer, GR226,206, was ineffective. Further, they were selective for dopaminergic pathways inasmuch as the firing rate of dorsal raphe serotonergic neurones and dialysate levels of serotonin were unaffected by GR205,171. Activation of mesocortical dopaminergic pathways may be involved in the influence of NK 1 antagonists upon mood. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Brain Research Elsevier

The selective neurokinin (NK) 1 antagonist, GR205,171, stereospecifically enhances mesocortical dopaminergic transmission in the rat: a combined dialysis and electrophysiological study

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Publisher
Elsevier
Copyright
Copyright © 2002 Elsevier Science B.V.
ISSN
0006-8993
DOI
10.1016/S0006-8993(02)02476-9
Publisher site
See Article on Publisher Site

Abstract

Upon acute, systemic administration, the selective, non-peptidergic NK 1 receptor antagonist, GR205,171, dose-dependently enhanced the firing rate of ventrotegmental dopaminergic neurones. Dialysate levels of dopamine were increased in the frontal cortex, but not in the striatum and nucleus accumbens, of conscious rats. These actions were stereospecific in that its less-active isomer, GR226,206, was ineffective. Further, they were selective for dopaminergic pathways inasmuch as the firing rate of dorsal raphe serotonergic neurones and dialysate levels of serotonin were unaffected by GR205,171. Activation of mesocortical dopaminergic pathways may be involved in the influence of NK 1 antagonists upon mood.

Journal

Brain ResearchElsevier

Published: May 10, 2002

References

  • Electroconvulsive shock increases tachykinin NK 1 receptors, but not the encoding mRNA, in rat cortex
    Burnet, P.W.J.; Miller, R.; Lewis, L.J.; Pei, Q.; Sharp, T.; Harrison, P.J.
  • Reversal of behavioural and electrophysiological correlates of experimental peripheral neuropathy by the NK 1 receptor antagonist GR205171 in rats
    Cumberbatch, M.J.; Carlson, E.; Wyatt, A.; Boyce, S.; Hill, R.G.; Rupniak, N.M.J.
  • Tachykinin NK 1 receptor antagonists enhance stress-induced c-fos in rat locus coeruleus
    Hahn, M.K.; Bannon, M.J.
  • Induction of burst firing in ventral tegmental area dopaminergic neurons by activation of serotonin (5-HT) 1A receptors: WAY 100,635-reversible actions of the highly selective ligands, flesinoxan and S 15535
    Lejeune, F.; Millan, M.J.
  • The induction of pain: an integrative review
    Millan, M.J.
  • Effect of intranigral substance P and neurokinin A injections on extracellular dopamine levels measured by microdialysis in the striatum and frontoparietal cortex of rats
    Reid, M.S.; Herrera-Marschitz, M.; Ungerstedt, U.
  • Increase of extracellular dopamine in the prefrontal cortex: a trait of drugs with antidepressant potential?
    Tanda, G.; Carboni, E.; Frau, R.; Di Chiara, G.

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