The role of IS 6110 in the evolution of Mycobacterium tuberculosis

The role of IS 6110 in the evolution of Mycobacterium tuberculosis Members of the Mycobacterium tuberculosis complex contain the transposable element IS 6110 which, due to its high numerical and positional polymorphism, has become a widely used marker in epidemiological studies. Here, we review the evidence that IS 6110 is not simply a passive or ‘junk’ DNA sequence, but that, through its transposable activity, it is able to generate genotypic variation that translates into strain-specific phenotypic variation. We also speculate on the role that this variation has played in the evolution of M. tuberculosis and conclude that the presence of a moderate IS 6110 copy number within the genome may provide the pathogen with a selective advantage that has aided its virulence. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Tuberculosis Elsevier

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Publisher
Elsevier
Copyright
Copyright © 2007 Elsevier Ltd
ISSN
1472-9792
DOI
10.1016/j.tube.2007.05.010
Publisher site
See Article on Publisher Site

Abstract

Members of the Mycobacterium tuberculosis complex contain the transposable element IS 6110 which, due to its high numerical and positional polymorphism, has become a widely used marker in epidemiological studies. Here, we review the evidence that IS 6110 is not simply a passive or ‘junk’ DNA sequence, but that, through its transposable activity, it is able to generate genotypic variation that translates into strain-specific phenotypic variation. We also speculate on the role that this variation has played in the evolution of M. tuberculosis and conclude that the presence of a moderate IS 6110 copy number within the genome may provide the pathogen with a selective advantage that has aided its virulence.

Journal

TuberculosisElsevier

Published: Sep 1, 2007

References

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