The role of CRF receptor subtypes in stress-induced behavioural responses

The role of CRF receptor subtypes in stress-induced behavioural responses The actions of corticotropin-releasing factor (CRF) and CRF-related peptides in the brain and periphery are mediated through multiple receptors. Two CRF receptor subtypes that differ markedly in their pharmacological profiles and anatomical distribution have been identified and characterized. Important advances have been made in understanding CRF and its actions through the development of specific CRF receptor antagonists, application of antisense oligonucleotides, and the production of transgenic mice lacking functional CRF 1 receptors. This chapter describes recent findings with respect to CRF-related peptides and CRF receptors and their role in stress-induced behaviours. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Pharmacology Elsevier

The role of CRF receptor subtypes in stress-induced behavioural responses

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Publisher
Elsevier
Copyright
Copyright © 2000 Elsevier Science B.V.
ISSN
0014-2999
DOI
10.1016/S0014-2999(00)00553-7
Publisher site
See Article on Publisher Site

Abstract

The actions of corticotropin-releasing factor (CRF) and CRF-related peptides in the brain and periphery are mediated through multiple receptors. Two CRF receptor subtypes that differ markedly in their pharmacological profiles and anatomical distribution have been identified and characterized. Important advances have been made in understanding CRF and its actions through the development of specific CRF receptor antagonists, application of antisense oligonucleotides, and the production of transgenic mice lacking functional CRF 1 receptors. This chapter describes recent findings with respect to CRF-related peptides and CRF receptors and their role in stress-induced behaviours.

Journal

European Journal of PharmacologyElsevier

Published: Sep 29, 2000

References

  • Behavioral responses to stress are intact in CRF-deficient mice
    Dunn, A.J.; Swiergiel, A.H.
  • Characterization of the behavioral profile of the non-peptide CRF receptor antagonist CP-154,526 in anxiety models in rodents. Comparison with diazepam and buspirone
    Griebel, G.; Perrault, G.; Sanger, D.J.
  • Corticotropin-releasing factor modulates dietary preference in nutritionally and physically stressed rats
    Heinrichs, S.C.; Koob, G.F.
  • The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety
    Holsboer, F.
  • Intra-amygdala injections of corticotropin releasing factor facilitate inhibitory avoidance learning and reduce exploratory behavior in rats
    Liang, K.C.; Lee, E.H.Y.
  • A non peptidic corticotropin releasing factor receptor antagonist attenuates fever and exhibits anxiolytic-like activity
    Lundkvist, J.; Chai, Z.; Teheranian, R.; Hasanvan, H.; Bartfai, T.; Jenck, F.; Widmer, U.; Moreau, J.-L.
  • Altered expression of type 2 CRH receptor mRNA in the VMH by glucocorticoids and starvation
    Makino, S.; Nishiyama, M.; Asaba, K.; Gold, P.W.; Hashimoto, K.
  • Antidepressant-like effects of CP-154,526, a selective CRF 1 receptor antagonist
    Mansbach, R.S.; Brooks, E.N.; Chen, Y.L.
  • Corticotropin-releasing factor but not urocortin is involved in adrenalectomy-induced adrenocorticotropin release
    Masuzawa, M.; Oki, Y.; Ozawa, M.; Watanabe, F.; Yoshimi, T.
  • CRF-deficient mice respond like wild-type mice to hypophagic stimuli
    Swiergiel, A.H.; Dunn, A.J.
  • Urocortin-like immunoreactivity in the substantia nigra, ventral tegmental area and Edinger–Westphal nucleus of rat
    Yamamoto, H.; Maeda, T.; Fujimura, M.; Fujimiya, M.

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