The presence of PEG on nanoparticles presenting the c[RGDfK]- and/or ATWLPPR peptides deeply affects the RTKs-AKT-GSK3β-eNOS signaling pathway and endothelial cells survival

The presence of PEG on nanoparticles presenting the c[RGDfK]- and/or ATWLPPR peptides deeply... International Journal of Pharmaceutics 568 (2019) 118507 Contents lists available at ScienceDirect International Journal of Pharmaceutics journal homepage: www.elsevier.com/locate/ijpharm The presence of PEG on nanoparticles presenting the c[RGDfK]- and/or ATWLPPR peptides deeply affects the RTKs-AKT-GSK3β-eNOS signaling pathway and endothelial cells survival a,b c,d b c c Tao Jia , Jéremy Ciccione , Thibault Jacquet , Manon Maurel , Titouan Montheil , d c a,b c a,b, Ahmad Mehdi , Jean Martinez , Béatrice Eymin , Gilles Subra , Jean-Luc Coll INSERM U1209, CNRS UMR 5309, Institute for Advanced Biosciences, F-38600 La Tronche, France Université. Grenoble Alpes, Institute for Advanced Biosciences, F-38600 La Tronche, France IBMM Université de Montpellier, CNRS, ENSCM, Montpellier, France ICGM Université de Montpellier, CNRS, ENSCM, Montpellier, France ARTIC L E I NF O ABSTRAC T Keywords: Covering the surface of a nanoparticle with polyethylene glycol (PEG) is a common way to prevent non-specific Angiogenesis interactions but how its presence impacts on the activity of targeting ligands is still poorly documented. We α ß integrin v 3 synthesized a set of 9 silica nanoparticles grafted with c[RGDfK]-, a peptide targeting integrin α ß (cRGD) and/ v 3 , Neuropilin 1 or with ATWLPPR, an anti-neuropilin 1 peptide http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Pharmaceutics Elsevier

The presence of PEG on nanoparticles presenting the c[RGDfK]- and/or ATWLPPR peptides deeply affects the RTKs-AKT-GSK3β-eNOS signaling pathway and endothelial cells survival

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Publisher
Elsevier
Copyright
Copyright © 2019 Elsevier B.V.
ISSN
0378-5173
D.O.I.
10.1016/j.ijpharm.2019.118507
Publisher site
See Article on Publisher Site

Abstract

International Journal of Pharmaceutics 568 (2019) 118507 Contents lists available at ScienceDirect International Journal of Pharmaceutics journal homepage: www.elsevier.com/locate/ijpharm The presence of PEG on nanoparticles presenting the c[RGDfK]- and/or ATWLPPR peptides deeply affects the RTKs-AKT-GSK3β-eNOS signaling pathway and endothelial cells survival a,b c,d b c c Tao Jia , Jéremy Ciccione , Thibault Jacquet , Manon Maurel , Titouan Montheil , d c a,b c a,b, Ahmad Mehdi , Jean Martinez , Béatrice Eymin , Gilles Subra , Jean-Luc Coll INSERM U1209, CNRS UMR 5309, Institute for Advanced Biosciences, F-38600 La Tronche, France Université. Grenoble Alpes, Institute for Advanced Biosciences, F-38600 La Tronche, France IBMM Université de Montpellier, CNRS, ENSCM, Montpellier, France ICGM Université de Montpellier, CNRS, ENSCM, Montpellier, France ARTIC L E I NF O ABSTRAC T Keywords: Covering the surface of a nanoparticle with polyethylene glycol (PEG) is a common way to prevent non-specific Angiogenesis interactions but how its presence impacts on the activity of targeting ligands is still poorly documented. We α ß integrin v 3 synthesized a set of 9 silica nanoparticles grafted with c[RGDfK]-, a peptide targeting integrin α ß (cRGD) and/ v 3 , Neuropilin 1 or with ATWLPPR, an anti-neuropilin 1 peptide

Journal

International Journal of PharmaceuticsElsevier

Published: Sep 10, 2019

References

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