International Journal of Pharmaceutics 568 (2019) 118507 Contents lists available at ScienceDirect International Journal of Pharmaceutics journal homepage: www.elsevier.com/locate/ijpharm The presence of PEG on nanoparticles presenting the c[RGDfK]- and/or ATWLPPR peptides deeply aﬀects the RTKs-AKT-GSK3β-eNOS signaling pathway and endothelial cells survival a,b c,d b c c Tao Jia , Jéremy Ciccione , Thibault Jacquet , Manon Maurel , Titouan Montheil , d c a,b c a,b, Ahmad Mehdi , Jean Martinez , Béatrice Eymin , Gilles Subra , Jean-Luc Coll INSERM U1209, CNRS UMR 5309, Institute for Advanced Biosciences, F-38600 La Tronche, France Université. Grenoble Alpes, Institute for Advanced Biosciences, F-38600 La Tronche, France IBMM Université de Montpellier, CNRS, ENSCM, Montpellier, France ICGM Université de Montpellier, CNRS, ENSCM, Montpellier, France ARTIC L E I NF O ABSTRAC T Keywords: Covering the surface of a nanoparticle with polyethylene glycol (PEG) is a common way to prevent non-speciﬁc Angiogenesis interactions but how its presence impacts on the activity of targeting ligands is still poorly documented. We α ß integrin v 3 synthesized a set of 9 silica nanoparticles grafted with c[RGDfK]-, a peptide targeting integrin α ß (cRGD) and/ v 3 , Neuropilin 1 or with ATWLPPR, an anti-neuropilin 1 peptide
International Journal of Pharmaceutics – Elsevier
Published: Sep 10, 2019
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