Available online at www.sciencedirect.com ScienceDirect The potential of Ion Mobility Mass Spectrometry for high-throughput and high-resolution lipidomics 1 1 Christine Hinz , Sonia Liggi and Julian L Grifﬁn Lipids are a large and highly diverse family of biomolecules, the same class, represents a signiﬁcant analytical chal- which play essential structural, storage and signalling roles in lenge in lipidomic studies, aiming to proﬁle the entire cells and tissues. Although traditional mass spectrometry lipid content (lipidome) of the studied samples. Cur- (MS) approaches used in lipidomics are highly sensitive and rently, high-resolution mass spectrometry (MS) ap- selective, lipid analysis remains challenging due to the proaches either alone (shotgun MS) or coupled with chemical diversity of lipid structures, multiple isobaric liquid chromatography (LC/MS) are commonly used. species and incomplete separation using many forms of However, insufﬁcient separation of isomeric and isobaric chromatography. Ion mobility (IM) separates ions in the gas species, very common in complex biological samples, is a phase based on their physicochemical properties. Addition of major challenge. Therefore, further analytical separation IM to the traditional lipidomic workﬂow both enhances methods are required to resolve isobaric lipid species, separation of complex lipid mixtures, beneﬁcial for lipid uncover the isomeric distribution of
Current Opinion in Chemical Biology – Elsevier
Published: Feb 1, 2018
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