The Otx family

The Otx family Otx1 and Otx2, the murine homologs of the Drosophila orthodenticle gene, play a remarkable role in specification and regionalization of forebrain and midbrain. Recently, genetic approaches have indicated that OTD, OTX1 and OTX2 have retained reciprocal functional equivalence in evolution, whereas their regulatory control has been remarkably modified. This suggests that during the evolution of the vertebrate brain, regulatory changes modulating the transcriptional and translational control of pre-existing gene functions might have favored the establishment of new morphogenetic pathways. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Genetics & Development Elsevier

Loading next page...
 
/lp/elsevier/the-otx-family-jX8iZp0m46
Publisher
Elsevier
Copyright
Copyright © 2002 Elsevier Science Ltd
ISSN
0959-437x
DOI
10.1016/S0959-437X(02)00318-0
Publisher site
See Article on Publisher Site

Abstract

Otx1 and Otx2, the murine homologs of the Drosophila orthodenticle gene, play a remarkable role in specification and regionalization of forebrain and midbrain. Recently, genetic approaches have indicated that OTD, OTX1 and OTX2 have retained reciprocal functional equivalence in evolution, whereas their regulatory control has been remarkably modified. This suggests that during the evolution of the vertebrate brain, regulatory changes modulating the transcriptional and translational control of pre-existing gene functions might have favored the establishment of new morphogenetic pathways.

Journal

Current Opinion in Genetics & DevelopmentElsevier

Published: Aug 1, 2002

References

  • Regionalization of the prosencephalic neural plate
    Rubenstein, J.L.R.; Shimamura, K.; Martinez, S.; Puelles, L.
  • Otx2 , Gbx2 and Fgf8 interact to position and maintain a mid-hindbrain organizer
    Joyner, A.L.; Liu, A.; Millet, S.
  • The midbrain-hindbrain boundary organizer
    Rhinn, M.; Brand, M.
  • Conserved usage of gap and homeotic genes in patterning the CNS
    Reichert, H.; Simeone, A.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off