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doses (Allais et al., 2020). The discrepancy between the low dose and non- monotonic effects of BFRs in the mammary gland and the linear response observed in the ovaries could be due to variations ...
Abstract The rodent uterus responds to acute estradiol (E2) treatment with a series of well characterized physiological responses . In a recent screen for genes involved in this response , we found ...
revealed that, as predicted from rodent studies, 2M females had a significantly longer AGD than 2F females (F. S. vom Saal, unpublished data). Fetal differentiation of the mammary gland in mice is influenced ...
” non- monotonic dose- response curve (see Fig. 3) is only recently being examined and appreciated. FINAL COMMON PATHWAYS AND BROAD CELLULAR IMPERATIVES In the past, we have most often studied signaling ...
other actions such as directly stimulating sperm production in the testes, milk secretion by mammary glands , bone growth, or the development of follicles in the ovaries. The three neuroendocrine axes ...
Scholar Alworth, L., Howdeshell, K., Ruhlen, R. et al. (1999) Uterine response to estradiol : low-dose facilitation and high-dose inhibition due to fetal exposure to diethylstilbestrol and methoxychlor in CD ...
, it has been hypothesized that BPA may induce adverse effects via the seven-transmembrane orphan receptor GRP30 which has been purported to be responsive to estradiol and BPA (Thomas and Dong 2006; Thomas ...
in tandem with the nervous system, which mainly is responsible for rapid and immediate responses , the approximately 30 different glands comprising the endocrine system tend to act in a slower and more ...
-life exposure to BPA in animals. These studies have linked BPA administered early and chronically at prenatal or prepubertal stages with morphological alterations in fetal mouse mammary glands (Munoz-de ...
mg/kg/d) in the F3 generation. Further, prenatal DEHP increased estradiol levels (F1 and F3), decreased testosterone levels (F1, F2, and F3), decreased progesterone levels (F2), altered gonadotropin ...
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