“Whoa! It’s like Spotify but for academic articles.”

Instant Access to Thousands of Journals for just $40/month

Try 2 weeks free now

The Inhibitory Effects of Cannabidiol on Systemic Malignant Tumors

To the Editor: The recent article by Johnson et al. 1 provided for highly stimulating reading. Cannabidiol may attenuate tumor growth in a number of other systemic malignancies. Decreased tumor growth in pulmonary malignancies is seen after administration of cannabidiol. Cannabidiol increases the expression of cyclooxygenase-2 within the cancerous cells. 2 Cannabidiol also induces tissue inhibitor of metalloproteinase-1 synthesis and activity. Peroxisome proliferator-activated receptor-gamma expression is augmented at the same time. Intercellular adhesion molecule-1 induction also is seen typically. 3 As a result, intratumoral apoptosis is markedly accentuated. Cannabidiol also downregulates the expression of plasminogen activator inhibitor-1. 4 Increased nuclear translocation of peroxisome proliferator-activated receptor-gamma accompanies the above changes. Tumor metastasis also is markedly attenuated.</P>Similar attenuation of tumor growth is seen in breast malignancies. It mediates this antineoplastic effect by attenuating mammalian target of rapamycin signaling. 5 Endoplasmic reticulum stress is typically accentuated and the cytoplasmic release of cytochrome C is markedly enhanced. ID1 expression also is inhibited at the same time. 6 On the other hand, ID2 expression is markedly upregulated. AKT inhibition accompanies the above changes. As a consequence, there is both increased apoptosis and intratumoral autophagy. Interestingly, beclin-1 plays a major role in these changes.</P>The above examples clearly illustrate the significant antineoplastic effects of cannabidiol. Hopefully, the next few years will see increased studies to fully and further evaluate these antineoplastic effects.</P> http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Pain and Symptom Management Elsevier
Loading next page...
1 Page

You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy unlimited access and
personalized recommendations from
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $40/month

Try 2 weeks free now

Explore the DeepDyve Library

How DeepDyve Works

Spend time researching, not time worrying you’re buying articles that might not be useful.

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from Springer, Elsevier, Nature, IEEE, Wiley-Blackwell and more.

All the latest content is available, no embargo periods.

See the journals in your area

Simple and Affordable Pricing

14-day free trial. Cancel anytime, with a 30-day money-back guarantee.

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Best Deal — 25% off

Annual Plan

  • All the features of the Professional Plan, but for 25% off!
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

billed annually