The Importance of Being Dolichol

The Importance of Being Dolichol ARTICLE NO. 243, 1–5 (1998) RC977828 BREAKTHROUGHS AND VIEWS The Importance of Being Dolichol Sharon S. Krag Department of Biochemistry, School of Hygiene and Public Health, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, Maryland 21205 E-mail: sskrag@welchlink.welch.jhu.edu Received November 15, 1997 Linear, long-chain isoprenoids, polyisoprenoids with chain lengths greater than thirty carbons, are ubiquitous membrane constituents now known to be involved in glycan synthesis. They are present in small amounts (0.1%) relative to glycerol-based phospholipids (1,2,3), and are thought not to form bilayers, but rather type II lamellar structures (4,5). There are two different types of polyisoprenoid lipids known - one with all the isoprene units in the polymer unsaturated and one with the isoprene unit of the polymer adjacent to the hydroxyl group (alpha isoprene) saturated. In this minireview, I will refer to the former as polyprenol and the latter as dolichol. An interesting feature of these polyisoprenoid lipids is that they are not present as a species of a single chain length, but are found in cells as a family of four or five different chain lengths, with one or two chain lengths predominating. For example, in Chinese hamster ovary (CHO) cells the predominant polyisoprenol http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biochemical and Biophysical Research Communications Elsevier

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Publisher
Elsevier
Copyright
Copyright © 1998 Elsevier Ltd
ISSN
0006-291x
DOI
10.1006/bbrc.1997.7828
pmid
9473469
Publisher site
See Article on Publisher Site

Abstract

ARTICLE NO. 243, 1–5 (1998) RC977828 BREAKTHROUGHS AND VIEWS The Importance of Being Dolichol Sharon S. Krag Department of Biochemistry, School of Hygiene and Public Health, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, Maryland 21205 E-mail: sskrag@welchlink.welch.jhu.edu Received November 15, 1997 Linear, long-chain isoprenoids, polyisoprenoids with chain lengths greater than thirty carbons, are ubiquitous membrane constituents now known to be involved in glycan synthesis. They are present in small amounts (0.1%) relative to glycerol-based phospholipids (1,2,3), and are thought not to form bilayers, but rather type II lamellar structures (4,5). There are two different types of polyisoprenoid lipids known - one with all the isoprene units in the polymer unsaturated and one with the isoprene unit of the polymer adjacent to the hydroxyl group (alpha isoprene) saturated. In this minireview, I will refer to the former as polyprenol and the latter as dolichol. An interesting feature of these polyisoprenoid lipids is that they are not present as a species of a single chain length, but are found in cells as a family of four or five different chain lengths, with one or two chain lengths predominating. For example, in Chinese hamster ovary (CHO) cells the predominant polyisoprenol

Journal

Biochemical and Biophysical Research CommunicationsElsevier

Published: Feb 4, 1998

References

  • Glycobiology
    Rosenwald, A.G.; Stanley, P.; McLachlan, K.R.; Krag, S.S.

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