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to the human U5 small ribonucleoprotein–associated 102-kD protein and to the yeast pre-mRNA splicing factors Prp1p and Prp6p . STA1 expression is upregulated by cold stress, and the sta1-1 mutant is defective ...
, it is not clear how SMU-2 homologues regulate pre-mRNA splicing . The human SMU-2 homologue does not appear to be a core component of the spliceosome, since it was not uniformly detected in different spliceosomal ...
spliceosomal complexes. These spliceosomal subcomplexes did not contain the bona fide splicing factors Prp1/Prp6/U5-102 K and Prp31 (27–30). Third, a complex associated with Prp1/Prp6/U5-102 K and Prp31 has been ...
to be a truly systemic splicing disease. Although these mutations cause widespread and important splicing defects, they are likely tolerated by the majority of human tissues but are critical for retinal cell ...
contains the related Lsm2 (Like Sm2) to Lsm8 proteins (Tharun, 2009). The initial step of splice site recognition comprises U1 snRNP binding to the 5′ splice site and U2 auxillary factor (U2AF) binding ...
similarity to human U5-116kD and yeast Snu114p, factors known to be components of the pre-mRNA splicing machinery (Fabrizio et al. 1997, Bartels et al. 2002, Coury et al. 2007, Moll et al. 2008). We found ...
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