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ARTICLE OPEN The histone demethylase Kdm6b regulates the maturation and + + cytotoxicity of TCRαβ CD8αα intestinal intraepithelial lymphocytes 1,2,8 1,2,8 1,2,8 1,2 1 3 2 1,2 Haohao Zhang , Yiming Hu ...
that expression of this maturation gene program in mouse cerebellar granule neurons (CGNs) requires dynamic changes in the genomic distribution of histone H3 lysine 27 trimethylation (H3K27me3), demonstrating ...
demethylase , and ASD-risk gene , Kdm6b . Interestingly, inhibition of the H3K27 methyltransferase EZH2 in newborn CGNs not only blocks the repression of progenitor genes but also impairs the induction of mature ...
histone demethylases coding genes Kdm5b, Kdm6a, and Kdm6b in oocytes. Moreover, we demonstrate that the aberrant H3K4me3 and H3K27me3 cause mis- expression of genes that are critical ...
known as lysine specific demethylase 6B ( KDM6B ). This is a member of the Fe(II)- and α-ketoglutarate-dependent demethylases reported to activate gene expression by removing tri-methylated histone 3 lysine ...
and histone demethylases (KDMs) [26]. Several KDMs of H3K4 (e.g. KDM1A, KDM5A, KDM5B), H3K9 (e.g. KDM4A, KDM4B), and H3K27 (e.g. KDM6A, KDM6B ) were shown to be expressed in embryos [18,20,27,28 ...
Scholar Crossref Search ADS PubMed WorldCat 16 Agger K , Cloos PA, Christensen J, et al. UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development . Nature . 2007 ; 449 ...
negative regulation of NFκB signaling. Depletion of the histone demethylase lysine (K)-specific demethylase 6B ( KDM6B ) downregulated IGFBP5 expression by increasing histone K27 methylation in the IGFBP5 ...
modification at term when the genes are upregulated. Bivalent epigenetic regulation by histone modifying enzymes may control the timing of labour. parturition, amnion, histone modifications, gene expression ...
are histone H3K27 demethylases involved in HOX gene regulation and development . Nature 449: 731 – 4 . Google Scholar OpenURL Placeholder Text WorldCat Agrawal R , Wessely O , Anand A , Singh L , Aggarwal RK ...
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