The essential role of zinc in growth

The essential role of zinc in growth Zinc is known to play a relevant role in growth and development. The basic mechanisms of action of this trace element are intimately linked to the structure and action of countless enzymes involved in many different metabolic processes. In this respect, when zinc specifically acts on cartilage growth it is involved in multiple enzymatic reactions which make this a multifactorial event. Thus, we may divide the actions of zinc into three distinct types: 1) action on taste and smell acuity, appetite regulation, and food consumption and regulation; 2) action on DNA and RNA synthesis stimulating a) cell replication and differentiation of chondrocytes, osteoblasts and fibroblasts; b) cell transcription culminating in the synthesis of somatomedin-C (liver), alkaline phosphatase, collagen and osteocalcin (bone), and c) protein, carbohydrate and lipid metabolism, that is intimately related to the mechanisms of smell, taste, appetite, and food consumption and utilization; 3) action on hormonal mediation by participating in a) GH synthesis and secretion is somatomammotroph cells, b) the action of GH on liver somatomedin-C production, and c) somatomedin-C activation in bone cartilage. In addition to these multiple functions, zinc also interacts with other hormones somehow related to bone growth such as testosterone, thyroid hormones, insulin, and vitamin D 3 . On the basis of the above considerations, we conclude that the integration of these mechanisms contributes to the perfect physiological functioning of bone. In the presence of zinc deficiency, this homeostasis is impaired, causing the weight-height deficiency detected in several species studied, the human species in particular. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nutrition Research Elsevier

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Publisher
Elsevier
Copyright
Copyright © 1995 Elsevier Ltd
ISSN
0271-5317
DOI
10.1016/0271-5317(95)00003-8
Publisher site
See Article on Publisher Site

Abstract

Zinc is known to play a relevant role in growth and development. The basic mechanisms of action of this trace element are intimately linked to the structure and action of countless enzymes involved in many different metabolic processes. In this respect, when zinc specifically acts on cartilage growth it is involved in multiple enzymatic reactions which make this a multifactorial event. Thus, we may divide the actions of zinc into three distinct types: 1) action on taste and smell acuity, appetite regulation, and food consumption and regulation; 2) action on DNA and RNA synthesis stimulating a) cell replication and differentiation of chondrocytes, osteoblasts and fibroblasts; b) cell transcription culminating in the synthesis of somatomedin-C (liver), alkaline phosphatase, collagen and osteocalcin (bone), and c) protein, carbohydrate and lipid metabolism, that is intimately related to the mechanisms of smell, taste, appetite, and food consumption and utilization; 3) action on hormonal mediation by participating in a) GH synthesis and secretion is somatomammotroph cells, b) the action of GH on liver somatomedin-C production, and c) somatomedin-C activation in bone cartilage. In addition to these multiple functions, zinc also interacts with other hormones somehow related to bone growth such as testosterone, thyroid hormones, insulin, and vitamin D 3 . On the basis of the above considerations, we conclude that the integration of these mechanisms contributes to the perfect physiological functioning of bone. In the presence of zinc deficiency, this homeostasis is impaired, causing the weight-height deficiency detected in several species studied, the human species in particular.

Journal

Nutrition ResearchElsevier

Published: Mar 1, 1995

References

  • Zinc in DNA replication and transcription
    Wu, F Y-H; Wu, C-W
  • Growth delay in Down syndrome and zinc sulphate supplementation
    Napolitano, G; Palka, G; Grimaldi, S; Giuliani, C; Laglia, G; Calabrese, G; Satta, MA; Neri, G; Monaco, F
  • Syndrome iron deficiency anemia, hepatosplenomegaly, hypogonadism, dwarfism and geophagia
    Prasad, AS; Halsted, JA; Nadimi, M
  • Zinc and reproduction
    Apgar, J
  • Experimental zinc deficiency in humans
    Prasad, AS; Rabbani, P; Abassi, A; Bowersox, E; Fox, MR
  • Teratogenic aspects of manganese, zinc, and copper nutrition
    Hurley, LS
  • Growth in juvenile diabetes mellitus
    Birkbeck, JA

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