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using assays that do not distinguish the intact hormones from their primary metabolites , conclusions on secretion of incretins after nutrient ingestion and their possible contribution to glucose ...
Diagnostics GmbH, Mannheim, Germany). Plasma samples were assayed for total GLP-1 immunoreactivity using an antiserum that reacts equally with intact GLP-1 and the primary (N-terminally truncated) metabolite ...
of intact GIP as well as its primary metabolite , GIP 3–42, are similar in type 2 diabetic patients and healthy subjects . Regul Pept . 2006 ; 137 : 168 – 72 . Google Scholar Crossref Search ADS PubMed ...
of GI organoids rather than primary cultures eliminates the need for a constant supply of freshly harvested tissue (Fig. 2g). Intestinal organoids are three-dimensional (3D) structures grown from stem ...
Abstract An analysis of all US Food and Drug Administration (FDA) approvals for protein-based assays through 2008 reveals 109 unique protein targets in plasma or serum, as well as 62 additional tests ...
, and applicable to intact biomaterials rich in chemical structural information. NMR requires minimal sample preparation and can be used to investigate a mixture of or several different metabolites in a single ...
< 0.009), while T½ of intact and metabolite forms of GLP-1 and GIP were comparable between groups (P > 0.121). Conclusions: Unexpectedly, degradation and elimination of the intact and metabolite forms ...
] and animals [35], as well with combined sympathetic stimulation and rapid heart rates [4]. In the presence of K+ATP channel blockade and thus higher distal coronary resistance, higher flow pulsatility would ...
that is able to counter its hyperglycaemic effect. Glucose-dependent insulinotropic peptide ( GIP ) (enhances insulin secretion), gastrin (can improve β-cell mass), and ghrelin antagonists (reduce hunger ...
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