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composition.29 Analysis of the effect of NOD2 and ATG16L1 risk alleles on the intestinal microbiota is complicated by established associations between the NOD2 and ATG16L1 risk alleles with disease subphenotype ...
Genet . 2002; 70: 845– 857. CrossRef Search ADS PubMed 14 Yazdanyar S , Weischer M, Nordestgaard BG. Genotyping for NOD2 genetic variants and crohn disease : a metaanalysis. Clin Chem . 2009; 55: 1950 ...
or nonhematopoietic lineages. Nod2 , microbiota , Peyer's patches, Crohn's disease , gut permeability, antimicrobial peptides The intestinal mucosa harbors the highest number and diversity of permanently associated ...
activity. The role of inflammasomes in inflammation associated with Crohn's disease and ulcerative colitis is discussed. Finally, mechanistic studies linking genetic polymorphisms in ATG16L and NOD2 ...
antimicrobial peptide phenotype and responses to intestinal injury in Nod1−/−; Nod2 −/− mice. A recent study in rodents with a mutation in the Crohn's disease -related gene Atg16L1 showed altered host phenotype ...
Abstract Background and Aims Historical and emerging data implicate fungi in Crohn’s disease [CD] pathogenesis. However, a causal link between mycobiota, dysregulated immunity, and any impact of NOD2 ...
.27 Like in other diseases associated with intestinal dysbiosis, it is unclear if the unbalanced microbiota is a causative factor or an effect of diabetes; however, various human and animal model ...
that will be benefited by insights derived from the intense investigation of the etiopathogenesis of the disease described by Crohn et al.1 Back to top Article Information Corresponding Author: Richard S . Blumberg, MD ...
in gastrointestinal disease . Nat Clin Pract Gastroenterol Hepatol. 2005; 2: 406– 415. 28. Ogura Y, Lala S , Xin W, et al. Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis. Gut. 2003; 52: 1591 ...
WorldCat 12. Kennedy NA , Lamb CA , Berry SH , et al. . ; UK IBD Genetics Consortium . The impact of NOD2 variants on fecal microbiota in Crohn’s disease and controls without gastrointestinal disease ...
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