The dynamics of nitric oxide release measured directly and in real time following repeated waves of cortical spreading depression in the anaesthetised cat

The dynamics of nitric oxide release measured directly and in real time following repeated waves... Cortical application of crystalline KCl in male cats anaesthetised with α -chloralose induced four transient negative deflections in cortical direct current (d.c.) potential. In vehicle treated animals d.c. shifts were associated with a hyperaemia and a multiphasic nitric oxide (NO) release. In these animals, the first negative shift in d.c. potential produced a significantly larger NO electrode current, when compared to subsequent cortical depolarisations. However, regional cerebrovascular laser Doppler flux (rCBF LDF ) increases were similar for each event. In l - N G -nitro- l -arginine ( l -NAME; 10 mg/kg i.v. infused over 30 min) treated animals, d.c. shifts were also associated with NO release following a multiphasic waveform and increase in rCBF LDF , but were significantly attenuated when compared to controls. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neuroscience Letters Elsevier

The dynamics of nitric oxide release measured directly and in real time following repeated waves of cortical spreading depression in the anaesthetised cat

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Publisher
Elsevier
Copyright
Copyright © 1997 Elsevier Science Ireland Ltd
ISSN
0304-3940
D.O.I.
10.1016/S0304-3940(97)00604-6
Publisher site
See Article on Publisher Site

Abstract

Cortical application of crystalline KCl in male cats anaesthetised with α -chloralose induced four transient negative deflections in cortical direct current (d.c.) potential. In vehicle treated animals d.c. shifts were associated with a hyperaemia and a multiphasic nitric oxide (NO) release. In these animals, the first negative shift in d.c. potential produced a significantly larger NO electrode current, when compared to subsequent cortical depolarisations. However, regional cerebrovascular laser Doppler flux (rCBF LDF ) increases were similar for each event. In l - N G -nitro- l -arginine ( l -NAME; 10 mg/kg i.v. infused over 30 min) treated animals, d.c. shifts were also associated with NO release following a multiphasic waveform and increase in rCBF LDF , but were significantly attenuated when compared to controls.

Journal

Neuroscience LettersElsevier

Published: Sep 5, 1997

References

  • Nitric oxide and prostaglandins interact to mediate arteriolar dilation during cortical spreading depression
    Meng, W.; Colonna, D.M.; Tobin, J.R.; Busija, D.W.

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