The dolichol pathway of N -linked glycosylation

The dolichol pathway of N -linked glycosylation The oligosaccharide substrate for the N -linked protein glycosylation is assembled at the membrane of the endoplasmic reticulum. Dolichyl pyrophosphate serves as a carrier in this biosynthetic pathway. In this review, we discuss the function of the lipid carrier dolichol in oligosaccharide assembly and give an overview of the biosynthesis of the different sugar donors required for the building of the oligosaccharide. Yeast genetic techniques have made it possible to identify many different loci encoding specific glycosyltransferases required for the precise and ordered assembly of the dolichyl pyrophosphate-linked oligosaccharide. Based on the knowledge obtained from studying this pathway in yeast, we compare it to the process of N -linked protein glycosylation in archaea. We suggest that N -linked glycosylation in eukaryotes and in archaea share a common evolutionary origin. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biochimica et Biophysica Acta (BBA) - General Subjects Elsevier

Loading next page...
 
/lp/elsevier/the-dolichol-pathway-of-n-linked-glycosylation-xOxn8DDLWB
Publisher
Elsevier
Copyright
Copyright © 1999 Elsevier Science B.V.
ISSN
0304-4165
DOI
10.1016/S0304-4165(98)00127-5
Publisher site
See Article on Publisher Site

Abstract

The oligosaccharide substrate for the N -linked protein glycosylation is assembled at the membrane of the endoplasmic reticulum. Dolichyl pyrophosphate serves as a carrier in this biosynthetic pathway. In this review, we discuss the function of the lipid carrier dolichol in oligosaccharide assembly and give an overview of the biosynthesis of the different sugar donors required for the building of the oligosaccharide. Yeast genetic techniques have made it possible to identify many different loci encoding specific glycosyltransferases required for the precise and ordered assembly of the dolichyl pyrophosphate-linked oligosaccharide. Based on the knowledge obtained from studying this pathway in yeast, we compare it to the process of N -linked protein glycosylation in archaea. We suggest that N -linked glycosylation in eukaryotes and in archaea share a common evolutionary origin.

Journal

Biochimica et Biophysica Acta (BBA) - General SubjectsElsevier

Published: Jan 6, 1999

References

  • Assembly of asparagine-linked oligosaccharides
    Kornfeld, R.; Kornfeld, S.
  • Topography of glycosylation in the rough endoplasmic reticulum and Golgi apparatus
    Hirschberg, C.B.; Snider, M.D.
  • Protein glycosylation in yeast
    Kukuruzinska, M.A.; Bergh, M.L.E.; Jackson, B.J.
  • A specific screen for oligosaccharyltransferase mutations identifies the 9 kDa OST5 protein required for optimal activity in vivo and in vitro
    Reiss, G.; te Heesen, S.; Gilmore, R.; Zufferey, R.; Aebi, M.
  • A defect in GTP synthesis affects mannose outer chain elongation in Saccharomyces cerevisiae
    Shimma, Y.; Nishikawa, A.; bin Kassim, B.; Eto, A.; Jigami, Y.
  • Large scale identification of genes involved in cell surface biosynthesis and architecture in Saccharomyces cerevisiae
    Lussier, M.; White, A.M.; Sheraton, J.; di Paolo, T.; Treadwell, J.; Southard, S.B.; Horenstein, C.I.; Chen-Weiner, J.; Ram, A.F.; Kapteyn, J.C.; Roemer, T.W.; Vo, D.H.; Bondoc, D.C.; Hall, J.; Zhong, W.W.; Sdicu, A.M.; Davies, J.; Klis, F.M.; Robbins, P.W.; Bussey, H.
  • Characterization and localization of a long-chain isoprenyltransferase activity in porcine brain: proposed role in the biosynthesis of dolichyl phosphate
    Crick, D.C.; Rush, J.S.; Waechter, C.J.
  • Identification of genes controlling growth polarity in the budding yeast Saccharomyces cerevisiae : a possible role of N -glycosylation and involvement of the exocyst complex
    Mondesert, G.; Clarke, D.J.; Reed, S.I.
  • Cloning and characterization of the ALG3 gene of Saccharomyces cerevisiae
    Aebi, M.; Gassenhuber, J.; Domdey, H.; Heesen, S.T.
  • Dolichyl-phosphomannose synthase from the archae Thermoplasma acidophilum
    Zhu, B.C.; Laine, R.A.
  • The isolation of a Dol-P-Man synthase from Ustilago maydis that functions in Saccharomyces cerevisiae
    Zimmerman, J.W.; Specht, C.A.; Cazares, B.X.; Robbins, P.W.
  • Deregulation of the first N -glycosylation gene, ALG7, perturbs the expression of G1 cyclins and cell cycle arrest in Saccharomyces cerevisiae
    Lennon, K.; Bird, A.; Kukuruzinska, M.A.
  • Chemo-enzymatic synthesis of a lipid-linked core trisaccharide of N -linked glycoproteins
    Flitsch, S.L.; Pinches, H.L.; Taylor, J.P.; Turner, N.J.
  • Isolation of the ALG6 locus of Saccharomyces cerevisiae required for glucosylation in the N -linked glycosylation pathway
    Reiss, G.; te Heesen, S.; Zimmerman, J.; Robbins, P.W.; Aebi, M.
  • Isolation and characterization of genes that promote the expression of inositol transporter gene ITR1 in Saccharomyces cerevisiae
    Nikawa, J.; Hosaka, K.
  • Transmembrane movement of a water-soluble analogue of mannosylphosphoryldolichol is mediated by an endoplasmic reticulum protein
    Rush, J.S.; Waechter, C.J.
  • Rates of membrane-associated reactions: reduction of dimensionality revisited
    McCloskey, M.A.; Poo, M.M.
  • Asparagine-linked glycosylation in Schizosaccharomyces pombe : functional conservation of the first step in oligosaccharide-lipid assembly
    Zou, J.; Scocca, J.R.; Krag, S.S.
  • Structure and biosynthesis of prokaryotic glycoproteins
    Lechner, J.; Wieland, F.
  • The STT3 protein is a component of the yeast oligosaccharyltransferase complex
    Spirig, U.; Glavas, M.; Bodmer, D.; Reiss, G.; Burda, P.; Lippuner, V.; Te Heesen, S.; Aebi, M.
  • The biochemistry and genetics of capsular polysaccharide production in bacteria
    Roberts, I.S.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off