Background: In ongoing studies in our lab we found that diet-induced dietary condition resulting in insulin resistance in Tg2576 mice coincided with a promotion of Alzheimer’s disease (AD)-type amyloid pathology and impaired cognitive functioning relative to normoglycemic Tg2576 mice (Ho et al., 2004). Objective(s): Most interestingly, we recently found that administration of the novel natural anti-diabetic agent NIC5-15 for 6 months decreased β-amyloid (Aβ) 1–40 and Aβ 1–42 peptide content in the cerebral cortex and hippocampal formations of insulin resistant Tg2576 mice. Methods: This reduction in Aβ 1–40 and Aβ 1–42 peptide content coincided with 1) inhibition of γ-secretase activity without influencing generation of the Notch cleavage product Notch-1, and 2) improved cognitive functioning at 12 months of age. Conclusions: The studies provide impetus for the development of the natural anti-diabetic agent NIC5-15 in AD treatment.</P>
Alzheimer's and Dementia – Elsevier
Published: Jul 1, 2005
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