Access the full text.
Sign up today, get unlimited access with DeepDyve Pro!
. (2020): Design , Synthesis and Pharmacological Profile of LUF7746, a Novel Covalent Partial Agonist for the Adenosine A1 Receptor. ChemRxiv. Preprint. https://doi.org/10.26434/chemrxiv.11903286.v1 Partial ...
, pharmacophore models of the A2AR agonists and the ENT1 inhibitors were constructed. Accordingly, potentially active compounds were designed and synthesized by chemical modification of adenosine , particularly ...
Human A3 adenosine receptor hA3AR has been implicated in gastrointestinal cancer, where its cellular expression has been found increased, thus suggesting its potential as a molecular target for novel ...
We report the design , synthesis , and validation of the novel compound photocaged N6-cyclopentyladenosine (cCPA) to achieve precisely localized and timed release of the parent adenosine A1 receptor ...
Based on the structure of the natural product andrographolide, a series of novel 12-quinoline substituted derivatives 9 were designed and synthesized. In preliminary biological evaluation ...
Due to the implication of adenosine in seizure suppression, adenosine -based therapies such as adenosine receptor (AR) agonists have been investigated. This study aimed at investigating thieno[2,3-b ...
in contributing toward the potency of adenophostins, the vicinal bisphosphate motif is not essential for activity at the IP3R, as always thought, and it is possible to design potent agonists with just two ...
computational, structure-based ligand design methodologies. Over the last decade, we have assessed the efficient synthesis of novel ligands specifically addressed to each of the four ARs. We herein review ...
for the synthesis of pyrimido[5′,4′:4,5]pyrrolo[1,2‐a][1,4]diazepine derivatives was developed, and 11 new adenosine A2A receptor antagonists were obtained. Preliminary investigations into the toxicology of fused 7 ...
‐targeted drugs, such as tolerance, addiction, respiratory depression, and constipation. For the development of novel Gi‐biased MOR agonists , the design , synthesis , and structure–activity relationship (SAR ...
Access the full text.
Sign up today, get unlimited access with DeepDyve Pro!