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OBJECTIVE: Peroxisome - proliferator -activated receptor-alpha (PPARα) has a central role in lipid metabolism. Mice lacking PPARα accumulate hepatic fat and are prone to late onset obesity. Leptin ...
Abstract Background The nuclear receptors peroxisome proliferator -activated receptor γ (PPARγ) and peroxisome proliferator -activated receptor δ (PPARδ) play central roles in regulating metabolism ...
but could have anti-carcinogenic protective effects . Cancer Metastasis Rev (2011) 30:619–640 DOI 10.1007/s10555-011-9320-1 Dissecting the role of peroxisome proliferator -activated receptor-β/δ (PPARβ/δ ...
Mellitus (T2DM). A common side effect of treatment with TZDs is weight gain2. Here we report a novel role for central nervous system (CNS) PPARγ in the regulation of energy balance. We found that both acute ...
tissues in addition to direct effect to assess the roles of PPARs and their agonists, such as thiazolidinedione and lipid-lowering fibrate drugs, in β-cells. Abbreviations INS Insulinoma PPAR peroxisome ...
Proteins belonging to the peroxisome proliferator -activated receptor γ coactivator 1 (PGC-1) family are key regulators of cellular energy homeostasis in a number of oxidative tissues, including ...
in the peroxisome proliferator -activated γ γ receptor 2 gene is not associated with postprandial responses to glucose or fat tolerance tests in young healthy subjects: the European Atherosclerosis Research Study II ...
, but the role of central LKB1 in the development of obesity remains unclear.ObjectiveThis study aims to explore the main role of LKB1 in POMC neurons on obesity, and reveal the underlying mechanism of central ...
or indirectly result in this differential response to training. The key direct effect discussed is carbohydrate binding, whereas the indirect effects include the metabolic shift toward fat oxidation, the increase ...
Peroxisome proliferator -activated receptor γ (PPARγ), a ligand-dependent transcription factor highly expressed in adipocytes, is a master regulator of adipogenesis and lipid storage, a central player ...
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