The Central Cannabinoid Receptor Inactivation Suppresses Endocrine Reproductive Functions

The Central Cannabinoid Receptor Inactivation Suppresses Endocrine Reproductive Functions The function of central cannabinoid (CB 1 ) receptor was investigated in the regulation of the pituitary–gonad axis in CB 1 receptor knockout male mouse. Serum luteinizing hormone (LH) and testosterone (T) levels and basal T secretion in vitro of testes were significantly decreased in mutant (CB 1 −/− ) mice. The receptor agonist, anandamide (ANA), suppressed LH and T secretion in wild type (CB 1 +/+ ) mice but had no effect in receptor inactivated animals. The results are the first descriptions indicating the direct action of CB 1 receptors on LH and T secretion and the immunohistological demonstration of CB 1 receptors in the Leydig cells. The results also indicate that CB 1 receptors are responsible for the effects of exogenous cannabinoids on reproductive functions. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biochemical and Biophysical Research Communications Elsevier

The Central Cannabinoid Receptor Inactivation Suppresses Endocrine Reproductive Functions

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Publisher
Elsevier
Copyright
Copyright © 2001 Academic Press
ISSN
0006-291x
D.O.I.
10.1006/bbrc.2001.4977
Publisher site
See Article on Publisher Site

Abstract

The function of central cannabinoid (CB 1 ) receptor was investigated in the regulation of the pituitary–gonad axis in CB 1 receptor knockout male mouse. Serum luteinizing hormone (LH) and testosterone (T) levels and basal T secretion in vitro of testes were significantly decreased in mutant (CB 1 −/− ) mice. The receptor agonist, anandamide (ANA), suppressed LH and T secretion in wild type (CB 1 +/+ ) mice but had no effect in receptor inactivated animals. The results are the first descriptions indicating the direct action of CB 1 receptors on LH and T secretion and the immunohistological demonstration of CB 1 receptors in the Leydig cells. The results also indicate that CB 1 receptors are responsible for the effects of exogenous cannabinoids on reproductive functions.

Journal

Biochemical and Biophysical Research CommunicationsElsevier

Published: Jun 8, 2001

References

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