The function of central cannabinoid (CB 1 ) receptor was investigated in the regulation of the pituitary–gonad axis in CB 1 receptor knockout male mouse. Serum luteinizing hormone (LH) and testosterone (T) levels and basal T secretion in vitro of testes were significantly decreased in mutant (CB 1 −/− ) mice. The receptor agonist, anandamide (ANA), suppressed LH and T secretion in wild type (CB 1 +/+ ) mice but had no effect in receptor inactivated animals. The results are the first descriptions indicating the direct action of CB 1 receptors on LH and T secretion and the immunohistological demonstration of CB 1 receptors in the Leydig cells. The results also indicate that CB 1 receptors are responsible for the effects of exogenous cannabinoids on reproductive functions.
Biochemical and Biophysical Research Communications – Elsevier
Published: Jun 8, 2001
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