The cell-death machine

The cell-death machine Apoptosis, or programmed cell death, is the physiological process whereby individual cells are deliberately eliminated to achieve homeostasis and proper metazoan development. Numerous genes have recently been identified that are involved in apoptosis: some are believed to encode death effectors, whereas others encode positive or negative regulators of the cell-death machine. Precisely how these various proteins interact in the molecular mechanism of apoptosis remains to be discovered. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Biology Elsevier

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Publisher
Elsevier
Copyright
Copyright © 1996 Elsevier Science Ltd
ISSN
0960-9822
D.O.I.
10.1016/S0960-9822(02)00541-9
Publisher site
See Article on Publisher Site

Abstract

Apoptosis, or programmed cell death, is the physiological process whereby individual cells are deliberately eliminated to achieve homeostasis and proper metazoan development. Numerous genes have recently been identified that are involved in apoptosis: some are believed to encode death effectors, whereas others encode positive or negative regulators of the cell-death machine. Precisely how these various proteins interact in the molecular mechanism of apoptosis remains to be discovered.

Journal

Current BiologyElsevier

Published: May 1, 1996

References

  • Programmed cell death in invertebrates
    Hengartner, MO
  • Purification of three cytotoxic lymphocyte granule serine proteases
    Shi, L; Kam, CM; Powers, JC; Aebersold, R; Greenberg, AH
  • Cell nucleus and DNA fragmentation are not required for apoptosis
    Schulze-Osthoff, K; Walczak, H; Droge, W; Krammer, PH
  • Bcl-2 and the regulation of programmed cell death
    Reed, JC
  • New members of the Bcl-2 family and their protein partners
    Farrow, SN; Brown, R
  • Mechanisms and functions of cell death
    Ellis, RE; Yuan, J; Horvitz, HR
  • Viral proteins E1B19K and p35 protect sympathetic neurons from cell death induced by NGF deprivation
    Martinou, I; Fernandez, PA; Missotten, M; White, E; Allet, B; Sadoul, R
  • Cell killing the Drosophila gene reaper
    White, K; Tahaoglu, E; Steller, H

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