The biphasic opening of the blood–brain barrier in the cortex and hippocampus after traumatic brain injury in rats

The biphasic opening of the blood–brain barrier in the cortex and hippocampus after traumatic... This study examined the time course of the blood–brain barrier (BBB) opening and correlated this with brain edema formation after a lateral controlled cortical impact (CCI) brain injury in rats. Quantitative measurement of Evans blue (EB) extravasation using fluorescence was employed at 2, 4, 6 h and 1, 2, 3, 4 and 7 days after injury. Brain edema was measured by specific gravity of the tissue at corresponding time points. Two prominent EB extravasations were observed at 4–6 h and 3-day after injury in the injury-site cortex and the ipsilateral hippocampus. Brain edema became progressively more severe over time and peaked at 24 h after injury and began to decline after day 3. These results suggest that there is a biphasic opening of the BBB after CCI brain injury and the second opening of the BBB does not contribute to a further increase in edema formation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neuroscience Letters Elsevier

The biphasic opening of the blood–brain barrier in the cortex and hippocampus after traumatic brain injury in rats

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Publisher
Elsevier
Copyright
Copyright © 1997 Elsevier Science Ireland Ltd
ISSN
0304-3940
D.O.I.
10.1016/S0304-3940(97)00239-5
Publisher site
See Article on Publisher Site

Abstract

This study examined the time course of the blood–brain barrier (BBB) opening and correlated this with brain edema formation after a lateral controlled cortical impact (CCI) brain injury in rats. Quantitative measurement of Evans blue (EB) extravasation using fluorescence was employed at 2, 4, 6 h and 1, 2, 3, 4 and 7 days after injury. Brain edema was measured by specific gravity of the tissue at corresponding time points. Two prominent EB extravasations were observed at 4–6 h and 3-day after injury in the injury-site cortex and the ipsilateral hippocampus. Brain edema became progressively more severe over time and peaked at 24 h after injury and began to decline after day 3. These results suggest that there is a biphasic opening of the BBB after CCI brain injury and the second opening of the BBB does not contribute to a further increase in edema formation.

Journal

Neuroscience LettersElsevier

Published: Apr 18, 1997

References

  • Quantitative evaluation of blood–brain barrier permeability following middle cerebral artery occlusion in rats
    Belayev, L.; Busto, R.; Zhao, W.; Ginsberg, M.D.
  • Biphasic edema development after experimental brain contusion in rat
    Holmin, S.; Mathiesen, T.
  • Development of prolonged focal cerebral edema and regional cation changes following experimental brain injury in the rat
    Soares, H.D.; Thomas, M.; Cloherty, K.; McIntosh, T.K.

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