1 <h5>Introduction</h5> Cardiolipin is a unique phospholipid with dimeric structure, carrying four acyl groups and two negative charges. It is exclusively found in bacterial and mitochondrial membranes, which are designed to generate an electrochemical potential for substrate transport and ATP synthesis. The name “cardiolipin” alludes to the tissue from which it was first isolated in 1942  . Indeed, cardiolipin is most abundant in mammalian hearts, and commercial preparations of cardiolipin are derived from heart tissue to this day. However, cardiolipin can be found in all mammalian tissues and throughout the eukaryotic kingdom, wherever mitochondria occur. For decades, the biomembrane function of cardiolipin has been unresolved, although it is widely believed that its function is related to its unique ability to interact with proteins. The recent identification of yeast genes encoding the cardiolipin biosynthetic enzymes and subsequent generation of cardiolipin deficient strains have provided powerful molecular tools to understand the biosynthesis and function of cardiolipin. The present review will address studies of the structure, biosynthesis, and function of cardiolipin, primarily in eukaryotes. In addition, the role of cardiolipin in mitochondrial biogenesis and its involvement in human disease is discussed. Finally, we pose several unanswered questions that are avenues
Progress in Lipid Research – Elsevier
Published: May 1, 2000
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
EndNoteExport to EndNote
ok to continue