The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions

The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions Members of the Bcl-2 family are crucial integrators of survival and death signals in higher eukaryotes. Although recent studies have provided novel and quite unexpected insights into the mechanisms by which these proteins might issue life permits or death sentences in cells, we are still on the way to fully understand their modes of action. This review provides a snapshot on where we are on this journey and how we may exploit our knowledge on this family of proteins to unveil the mysteries of immune regulation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Immunology Elsevier

The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions

Molecular Immunology, Volume 39 (11) – Jan 1, 2003

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Publisher
Elsevier
Copyright
Copyright © 2003 Elsevier Science Ltd
ISSN
0161-5890
DOI
10.1016/S0161-5890(02)00252-3
Publisher site
See Article on Publisher Site

Abstract

Members of the Bcl-2 family are crucial integrators of survival and death signals in higher eukaryotes. Although recent studies have provided novel and quite unexpected insights into the mechanisms by which these proteins might issue life permits or death sentences in cells, we are still on the way to fully understand their modes of action. This review provides a snapshot on where we are on this journey and how we may exploit our knowledge on this family of proteins to unveil the mysteries of immune regulation.

Journal

Molecular ImmunologyElsevier

Published: Jan 1, 2003

References

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