The anxiolytic-like effect of metabotropic glutamate receptor antagonists after intrahippocampal injection in rats

The anxiolytic-like effect of metabotropic glutamate receptor antagonists after intrahippocampal... Using the conflict drinking Vogel test in rats as a model we examined the anxiolytic-like activity, after their intrahippocampal administration of ( S )-4-carboxy-3-hydroxyphenyl-glycine (S-4C3H-PG), ( RS )-α-methylserine- O -phosphate-monophenyl ester (MSOPPE) and ( RS )-α-methylserine- O -phosphate (MSOP), the antagonists of the I, the II and the III group of metabotropic glutamate receptors (mGlu receptors), respectively. The results indicate that S-4C3H-PG and MSOP produced a dose-dependent anticonflict effect in rats, which was unrelated to a reduced perception of the stimulus or to an increased thirst drive. The hippocampus may be one of the neuroanatomical sites of the anxiolytic-like effects of both mGlu receptor antagonists. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Pharmacology Elsevier

The anxiolytic-like effect of metabotropic glutamate receptor antagonists after intrahippocampal injection in rats

Loading next page...
 
/lp/elsevier/the-anxiolytic-like-effect-of-metabotropic-glutamate-receptor-0gAbOJH8Ep
Publisher
Elsevier
Copyright
Copyright © 1997 Elsevier Science B.V.
ISSN
0014-2999
DOI
10.1016/S0014-2999(96)00941-7
Publisher site
See Article on Publisher Site

Abstract

Using the conflict drinking Vogel test in rats as a model we examined the anxiolytic-like activity, after their intrahippocampal administration of ( S )-4-carboxy-3-hydroxyphenyl-glycine (S-4C3H-PG), ( RS )-α-methylserine- O -phosphate-monophenyl ester (MSOPPE) and ( RS )-α-methylserine- O -phosphate (MSOP), the antagonists of the I, the II and the III group of metabotropic glutamate receptors (mGlu receptors), respectively. The results indicate that S-4C3H-PG and MSOP produced a dose-dependent anticonflict effect in rats, which was unrelated to a reduced perception of the stimulus or to an increased thirst drive. The hippocampus may be one of the neuroanatomical sites of the anxiolytic-like effects of both mGlu receptor antagonists.

Journal

European Journal of PharmacologyElsevier

Published: Jan 29, 1997

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off