The 5-HT 1A receptor is not involved in emotional stress-induced rises in stress hormones

The 5-HT 1A receptor is not involved in emotional stress-induced rises in stress hormones To determine whether emotional stress-induced rises in stress hormone levels are mediated by activation of 5-HT 1A receptors, we studied the effects of the selective 5-HT 1A receptor antagonist, N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl) cyclohexanecarboxamide trihydrochloride (WAY-100635) on plasma ACTH, corticosterone, prolactin, and glucose levels in the conditioned ultrasonic vocalisation (USV) model in adult rats. The effects of WAY-100635 on USVs were also investigated in this paradigm. WAY-100635 (0.3, 1, and 3 mg/kg SC) had no clear effects on basal plasma ACTH, corticosterone, and glucose levels, but the 3 mg/kg dose significantly increased the plasma prolactin levels. The increases in plasma ACTH, corticosterone, and prolactin levels induced by the USV procedure were not affected by WAY-100635. This indicates that the 5-HT 1A receptor does not play a major role in the distress-induced activation of the hypothalamic-pituitary-adrenal axis and prolactin secretion. The USVs were significantly enhanced by low doses of WAY-100635 (0.03 and 0.3 mg/kg SC), whereas higher doses (1.0 and 3.0 mg/kg SC) had no effect. These findings suggest that blockade of 5-HT 1A receptors during stress may enhance the behavioural stress-response. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pharmacology Biochemistry and Behavior Elsevier

The 5-HT 1A receptor is not involved in emotional stress-induced rises in stress hormones

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Publisher
Elsevier
Copyright
Copyright © 1996 Elsevier Ltd
ISSN
0091-3057
eISSN
1873-5177
DOI
10.1016/S0091-3057(96)00088-3
Publisher site
See Article on Publisher Site

Abstract

To determine whether emotional stress-induced rises in stress hormone levels are mediated by activation of 5-HT 1A receptors, we studied the effects of the selective 5-HT 1A receptor antagonist, N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl) cyclohexanecarboxamide trihydrochloride (WAY-100635) on plasma ACTH, corticosterone, prolactin, and glucose levels in the conditioned ultrasonic vocalisation (USV) model in adult rats. The effects of WAY-100635 on USVs were also investigated in this paradigm. WAY-100635 (0.3, 1, and 3 mg/kg SC) had no clear effects on basal plasma ACTH, corticosterone, and glucose levels, but the 3 mg/kg dose significantly increased the plasma prolactin levels. The increases in plasma ACTH, corticosterone, and prolactin levels induced by the USV procedure were not affected by WAY-100635. This indicates that the 5-HT 1A receptor does not play a major role in the distress-induced activation of the hypothalamic-pituitary-adrenal axis and prolactin secretion. The USVs were significantly enhanced by low doses of WAY-100635 (0.03 and 0.3 mg/kg SC), whereas higher doses (1.0 and 3.0 mg/kg SC) had no effect. These findings suggest that blockade of 5-HT 1A receptors during stress may enhance the behavioural stress-response.

Journal

Pharmacology Biochemistry and BehaviorElsevier

Published: Oct 1, 1996

References

  • A pharmacological profile of the silent 5-HT 1A receptor antagonist, WAY-100635
    Forster, E.A.; Cliffe, I.A.; Bill, D.J.; Dover, G.M.; Jones, D.; Reilly, Y.; Fletcher, A.
  • The anxiolytic effects of flesinoxan, a 5-HT 1A receptor agonist, are not related to its neuroendocrine effects
    Groenink, L.; Van der Gugten, J.; Verdouw, P.M.; Maes, R.A.A.; Olivier, B.

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