Journal of Photochemistry and Photobiology A: Chemistry 355 (2018) 338–349 Contents lists available at ScienceDirect Journal of Photochemistry and Photobiology A: Chemistry journal home page : www.elsevier.com/locat e/jphotochem Tetraphenylethylene-based gemini surfactant as nonviral gene delivery system: DNA complexation, gene transfection and cellular tracking a,1 a,1 a a a, b, Ke-Xin Zhang , Ai-Xiang Ding , Zheng-Li Tan , You-Di Shi , Zhong-Lin Lu *, Lan He ** Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China National Institute for Food and Drug Control, Institute of Chemical Drug Control, TianTanXiLi 2, Beijing, 100050, China A R T I C L E I N F O A B S T R A C T Article history: Gemini surfactant (GS) has been proved to be a powerful system for nonviral gene delivery. Herein, a Received 4 July 2017 Received in revised form 5 August 2017 family of tetraphenylethylene (TPE)-based GS possessing different lengths of hydrophobic tails and Accepted 8 August 2017 different linkages between the TPE and aneN moieties (1a, 2a, 1b and 2b) were synthesized for Available online 12 August 2017 facilitating DNA condensation, promoting gene transfection and tracing cellular fate of GS/DNA complex.
Journal of Photochemistry and Photobiology A: Chemistry – Elsevier
Published: Mar 15, 2018
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