Temporal profile of nuclear DNA fragmentation in situ in gerbil hippocampus following transient forebrain ischemia

Temporal profile of nuclear DNA fragmentation in situ in gerbil hippocampus following transient... To determine the time course of nuclear DNA damage in the gerbil hippocampus following transient ischemia, brain sections 48, 72, 96 h and 7 days following 5 min ischemia were evaluated by a specific in situ labeling method of DNA breaks. After 72 h, only the neurons located in the medial part of the CA1 sector were labeled. And then, DNA damage extended to the lateral part of the sector with time. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Brain Research Elsevier

Temporal profile of nuclear DNA fragmentation in situ in gerbil hippocampus following transient forebrain ischemia

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Publisher
Elsevier
Copyright
Copyright © 1995 Elsevier Science B.V. All rights reserved
ISSN
0006-8993
D.O.I.
10.1016/0006-8993(94)01363-M
Publisher site
See Article on Publisher Site

Abstract

To determine the time course of nuclear DNA damage in the gerbil hippocampus following transient ischemia, brain sections 48, 72, 96 h and 7 days following 5 min ischemia were evaluated by a specific in situ labeling method of DNA breaks. After 72 h, only the neurons located in the medial part of the CA1 sector were labeled. And then, DNA damage extended to the lateral part of the sector with time.

Journal

Brain ResearchElsevier

Published: Feb 13, 1995

References

  • Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
    Gavrieli, Y.; Sherman, Y.; Ben-Sasson, S.A.
  • Temporal profile of neuronal damage in a model of transient forebrain ischemia
    Pulsinelli, W.A.; Brierley, J.B.; Plum, F.

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