Temporal and spatial dynamics of rabies viruses in China and Southeast Asia

Temporal and spatial dynamics of rabies viruses in China and Southeast Asia Phylogenetic studies have revealed a profound understanding about the biodiversity of rabies viruses in China, but little is known about their evolutionary dynamics in the country. In the present study, the complete G gene sequences of 33 rabies virus isolates (RABVs) isolated from distinct Chinese provinces were determined and phylogenetic analysis was conducted using these G sequences and 93 others retrieved from GenBank representing China and Southeast Asia. Further evolutionary history of RABV was estimated using a Bayesian Markov chain Monte Carlo method to understand the temporal and spatial dynamics of this virus. Results showed that rabies viruses in China and Southeast Asia share a common ancestor and form 2 clades with each being further divided into 3 lineages. The time of the most recent common ancestor of current RABV strains was estimated to be year 1654 (1514–1812) and the viruses circulating in Southeast Asia likely derived from China. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Virus Research Elsevier

Temporal and spatial dynamics of rabies viruses in China and Southeast Asia

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Publisher
Elsevier
Copyright
Copyright © 2010 Elsevier B.V.
ISSN
0168-1702
D.O.I.
10.1016/j.virusres.2010.02.019
Publisher site
See Article on Publisher Site

Abstract

Phylogenetic studies have revealed a profound understanding about the biodiversity of rabies viruses in China, but little is known about their evolutionary dynamics in the country. In the present study, the complete G gene sequences of 33 rabies virus isolates (RABVs) isolated from distinct Chinese provinces were determined and phylogenetic analysis was conducted using these G sequences and 93 others retrieved from GenBank representing China and Southeast Asia. Further evolutionary history of RABV was estimated using a Bayesian Markov chain Monte Carlo method to understand the temporal and spatial dynamics of this virus. Results showed that rabies viruses in China and Southeast Asia share a common ancestor and form 2 clades with each being further divided into 3 lineages. The time of the most recent common ancestor of current RABV strains was estimated to be year 1654 (1514–1812) and the viruses circulating in Southeast Asia likely derived from China.

Journal

Virus ResearchElsevier

Published: Jun 1, 2010

References

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