10.1016/j.neulet.2017.07.007

10.1016/j.neulet.2017.07.007 Article history: Neurons frequently show an imbalance in expression of the 3 untranslated region (3 UTR) relative to the Received 8 May 2017 coding DNA sequence (CDS) region of mature messenger RNAs (mRNA). The ratio varies among different Received in revised form 1 July 2017 cells or parts of the brain. The Map2 protein levels per cell depend on the 3 UTR-to-CDS ratio rather than Accepted 5 July 2017 the total mRNA amount, which suggests powerful regulation of protein expression by 3 UTR sequences. Available online 8 July 2017 Here we found that MAPT (the microtubule-associated protein tau gene) 3 UTR levels are particularly high with respect to other genes; indeed, the 3 UTR-to-CDS ratio of MAPT is balanced in healthy brain in mouse Keywords: and human. The tau protein accumulates in Alzheimer diseased brain. We nonetheless observed that the Tau (MAPT) levels of RNA encoding MAPT/tau were diminished in these patients’ brains. To explain this apparently 3 UTR contradictory result, we studied MAPT mRNA stoichiometry in coding and non-coding regions, and found CDS that the 3 UTR-to-CDS ratio was higher in the hippocampus of Alzheimer disease patients, with higher mRNA Alzheimer disease tau protein but lower total mRNA http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

10.1016/j.neulet.2017.07.007

Elsevier — Jun 11, 2020

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Abstract

Article history: Neurons frequently show an imbalance in expression of the 3 untranslated region (3 UTR) relative to the Received 8 May 2017 coding DNA sequence (CDS) region of mature messenger RNAs (mRNA). The ratio varies among different Received in revised form 1 July 2017 cells or parts of the brain. The Map2 protein levels per cell depend on the 3 UTR-to-CDS ratio rather than Accepted 5 July 2017 the total mRNA amount, which suggests powerful regulation of protein expression by 3 UTR sequences. Available online 8 July 2017 Here we found that MAPT (the microtubule-associated protein tau gene) 3 UTR levels are particularly high with respect to other genes; indeed, the 3 UTR-to-CDS ratio of MAPT is balanced in healthy brain in mouse Keywords: and human. The tau protein accumulates in Alzheimer diseased brain. We nonetheless observed that the Tau (MAPT) levels of RNA encoding MAPT/tau were diminished in these patients’ brains. To explain this apparently 3 UTR contradictory result, we studied MAPT mRNA stoichiometry in coding and non-coding regions, and found CDS that the 3 UTR-to-CDS ratio was higher in the hippocampus of Alzheimer disease patients, with higher mRNA Alzheimer disease tau protein but lower total mRNA

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