Acta Biomaterialia 71 (2018) 351–362 Contents lists available at ScienceDirect Acta Biomaterialia journal homepage: www.elsevier.com/locate/actabiomat Full length article Targeting tumor hypoxia with stimulus-responsive nanocarriers in overcoming drug resistance and monitoring anticancer efﬁcacy a,1 a,1 a a a a Zhiqi Xie , Wangwei Guo , Ningning Guo , Mingyi Huangfu , Huina Liu , Mengting Lin , b b a b a,⇑ a,⇑ WenHong Xu , Jiejian Chen , TianTian Wang , Qichun Wei , Min Han , Jianqing Gao College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China Department of Radiation Oncology, Key Laboratory of Cancer Prevention and Intervention, The Second Afﬁliated Hospital, Zhejiang University, College of Medicine, Hangzhou 310058, PR China article i nfo abstract Article history: Although existing nanomedicines have focused on the tumor microenvironment with the goal of improv- Received 9 October 2017 ing the effectiveness of conventional chemotherapy, the penetration of a tumor’s core still represents a Received in revised form 23 February 2018 formidable barrier for existing drug delivery systems. Therefore, a novel multifunctional hypoxia- Accepted 6 March 2018 induced size-shrinkable nanoparticle has been designed to increase the penetration of drugs, nucleic Available online 13 March 2018 acids, or probes into tumors. This
Acta Biomaterialia – Elsevier
Published: Apr 15, 2018
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