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Tumor metastasis is the main cause of death in advanced colorectal cancer. Our previous research showed that upregulation of KIAA1199 predicted poorer outcomes, and promoted cell motility and tumor ...
Tumor metastasis is the major cause of death from ovarian cancer. Therefore, targeted therapy, which could prevent the ability of cells to metastasize to different organs, is an effective treatment ...
considered a potential target for cancer therapy, especially in tumor metastasis prevention . However, the biological correlation between TRPV4 and tumor metastasis , as well as the specific role of TRPV4 ...
with tumor progression and metastasis , and whether endosialin has the potential to act as a novel therapeutic target in osteosarcoma (OS) using MORAb-004/ontuxizumab, a humanized monoclonal antibody, which ...
could be a therapeutic target in the context of preventing tumor invasion and metastasis . Background The enhancement of cell motility is a critical event during tumor cell spreading. Since myosin light ...
the accumulation of PAF and further prevented the increase in cell motility seen previously when cells were exposed to CSE. Thus, iPLA2 or PAF may represent a therapeutic target to manage metastatic disease ...
targeting with repositioned drugs. In fact, the MACC1-β-catenin-S100A4 axis by statins (MACC1) and niclosamide (S100A4) synergized in inhibiting cancer cell motility in vitro and metastasis in vivo. The MACC1 ...
Increasing cell mobility is the basis of tumor invasion and metastasis , and is therefore a therapeutic target for preventing the spread of many types of cancer. Septins are a family of cytoskeletal ...
The 90‐kDa heat shock protein (Hsp90α) has been identified on the surface of cancer cells , and is implicated in tumor invasion and metastasis , suggesting that it is a potentially important target ...
-to-mesenchymal transition (EMT) has a prominent role in the early steps of tumor progression and metastasis by initiating polarized epithelial cell transition into motile mesenchymal cells . Accumulating evidence ...
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