Targeting Heat Shock Protein 70 as an antiviral strategy against grass carp reovirus infection

Targeting Heat Shock Protein 70 as an antiviral strategy against grass carp reovirus infection •HSP70 was a host factor that interacted with GCRV on CIK cells.•VER155008 and pifithrin-μ were working to inhibit infection by perturbing the entry stage of the GCRV life cycle.•Fully functional HSP70 was required for entry of GCRV into CIK cells. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Virus Research Elsevier

Targeting Heat Shock Protein 70 as an antiviral strategy against grass carp reovirus infection

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier B.V.
ISSN
0168-1702
D.O.I.
10.1016/j.virusres.2018.01.005
Publisher site
See Article on Publisher Site

Abstract

•HSP70 was a host factor that interacted with GCRV on CIK cells.•VER155008 and pifithrin-μ were working to inhibit infection by perturbing the entry stage of the GCRV life cycle.•Fully functional HSP70 was required for entry of GCRV into CIK cells.

Journal

Virus ResearchElsevier

Published: Mar 2, 2018

References

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