Protein nanoparticles can be used to encapsulate, protect, and deliver hydrophobic bioactive agents however, they are often unstable to environmental stresses. In this study, the impact of electrostatic deposition of a biopolymer coating (alginate/gelatin) on the physicochemical and functional properties of curcumin-loaded zein nanoparticles was determined. The pH stability of the zein nanoparticles was greatly improved by the biopolymer coatings, with a 7:3 w/w alginate-to-gelatin ratio being the most effective at inhibiting particle aggregation from pH 3 to 7. The optimized biopolymer-coated nanoparticles remained stable to aggregation during long-term storage, and were resistant to heat treatment at 80 °C for up to 40 min in 10% aqueous sucrose solutions (pH 4.5). The in vitro bioaccessibility of curcumin was appreciably higher (22.4%) when it was encapsulated within biopolymer-coated zein nanoparticles than when it was not encapsulated (<8%). This effect was mainly attributed to the ability of the nanoparticles to inhibit curcumin degradation and increase curcumin solubility within the simulated gastrointestinal tract (GIT). The in vitro antioxidant capacity of curcumin after exposure to the simulated GIT was also greatly improved by encapsulation within the nanoparticles, as demonstrated by much stronger ABTS+· radical scavenging and ferric ion reducing power. These results suggest that biopolymer-coated zein nanoparticles may be an effective oral delivery system for curcumin that could be used in functional foods or beverages.
Food Hydrocolloids – Elsevier
Published: Jun 1, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.
All for just $49/month
Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.
Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.
It’s easy to organize your research with our built-in tools.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera