T-lymphocyte concentrations of cholecystokinin-8 and beta-endorphin in eating disorders: II. Bulimia nervosa

T-lymphocyte concentrations of cholecystokinin-8 and beta-endorphin in eating disorders: II.... Concentrations of cholecystokinin-8 (CCK-8) and β-endorphin (β-EP) in T-lymphocytes of 26 women with bulimia nervosa (BN) and in 26 age- and sex-matched healthy comparison subjects were measured. Ten patients were then treated with 300 mg/day of fluvoxamine, p.o., and five patients were treated with 300 mg/day of amineptine, p.o., for 4 months. Concentrations of the two peptides were measured again after 1, 2, and 4 months of therapy. Basal CCK-8 values were significantly lower in patients than in healthy subjects. During fluvoxamine therapy, CCK-8 values increased, reaching normal levels by month 4 of treatment. No such increase occurred during amineptine therapy. Baseline β-EP values were normal in the bulimic patients but had declined by month 4 of fluvoxamine therapy. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychiatry Research Elsevier

T-lymphocyte concentrations of cholecystokinin-8 and beta-endorphin in eating disorders: II. Bulimia nervosa

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Publisher
Elsevier
Copyright
Copyright © 1995 Elsevier Ltd
ISSN
0165-1781
DOI
10.1016/0165-1781(95)02674-6
Publisher site
See Article on Publisher Site

Abstract

Concentrations of cholecystokinin-8 (CCK-8) and β-endorphin (β-EP) in T-lymphocytes of 26 women with bulimia nervosa (BN) and in 26 age- and sex-matched healthy comparison subjects were measured. Ten patients were then treated with 300 mg/day of fluvoxamine, p.o., and five patients were treated with 300 mg/day of amineptine, p.o., for 4 months. Concentrations of the two peptides were measured again after 1, 2, and 4 months of therapy. Basal CCK-8 values were significantly lower in patients than in healthy subjects. During fluvoxamine therapy, CCK-8 values increased, reaching normal levels by month 4 of treatment. No such increase occurred during amineptine therapy. Baseline β-EP values were normal in the bulimic patients but had declined by month 4 of fluvoxamine therapy.

Journal

Psychiatry ResearchElsevier

Published: Nov 29, 1995

References

  • A comparison, between the effect of cholecystokinin octapeptide and apomorphine on ingestion of intraorally administered sucrose, in male rats
    Bednar, I.; Qureshi, G.A.; Sodersten, P.
  • T-lymphocyte cholecystokinin-8 and beta-endorphin concentrations in eating disorders: I. Anorexia nervosa
    Brambilla, F.; Brunetta, M.; Draisci, A.; Peirone, A.; Perna, G.; Sacerdote, P.; Manfredi, B.; Panerai, A.
  • Differences in the plasma betaendorphin, levels of bulimics
    Fullerton, D.T.; Swift, W.J.; Getto, C.J.; Carlson, J.H.; Gutzman, L.D.
  • Development and validation of a multidimensional eating disorder inventory for anorexia nervosa and bulimia
    Garner, D.M.; Olmstead, M.P.; Polivy, J.
  • Perception of hunger and satiety induced by 2-deoxy- D -glucose in anorexia nervosa and bulimia nervosa
    Nakai, Y.; Kinoshita, F.; Koh, T.; Tsujii, S.; Tsukuada, T.

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