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findingsThe balance between regulatory CD4 T cells , known to control autoimmunity , and effector CD4 T cells , that recognize liver self-antigens and mediate the liver inflammation, appears central in AIH immune ...
cellular immune attack in the pathogenesis of autoimmune hepatitis (AIH). Immunohistochemical studies, focused on the phenotype of inflammatory cells infiltrating the liver parenchyma, have shown ...
of autoantibodies and interface hepatitis on liver histology. AIH arises in genetically predisposed individuals when a trigger, such as exposure to a virus, leads to a T cell -mediated autoimmune response directed ...
multiple aspects of the immune response in different pathological settings, including autoimmunity . NKT cells have also been implicated in the immunopathogenesis of autoimmune hepatitis , and in this review ...
Autoimmune hepatitis is associated with interactive cell populations of the innate and adaptive immune systems, and these populations are amenable to therapeutic manipulation. The goals ...
Targeting antigens to the liver by glycosylation promotes antigen-specific immune tolerance via the expansion of regulatory T cells and prevents autoimmunity in a mouse model of type-1 diabetes. news ...
Background: In the pathology of autoimmune hepatitis the immunity mechanism of T ‐helper 1 (Th1) and Th2 cells was recently evaluated. The purpose of the present study was to measure the mRNA levels ...
SubsetsRegulatory T cells (Tregs) are important mediators of immune tolerance to self-antigens, and their impairment may cause autoimmune diseases [1,2]. However, the regulatory function of Tregs can also limit ...
Autoimmune liver diseases (AILD) include autoimmune hepatitis (AIH), primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). These immune -mediated liver diseases involve a break ...
Molecular chaperones influence the immunogenicity of peptides and the activation of effector T cells , and their pathogenic roles in autoimmune hepatitis are unclear. Heat shock proteins are pivotal ...
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