Systemic administration of guanfacine improves food-motivated impulsive choice behavior primarily via direct stimulation of postsynaptic α2A-adrenergic receptors in rats

Systemic administration of guanfacine improves food-motivated impulsive choice behavior primarily... •Guanfacine improved food-motivated impulsive choices in the delay discounting task.•Stimulation of the α2A-adrenergic receptor was involved in the effect of guanfacine.•A selective noradrenergic neurotoxin did not affect the effect of guanfacine. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Behavioural Brain Research Elsevier

Systemic administration of guanfacine improves food-motivated impulsive choice behavior primarily via direct stimulation of postsynaptic α2A-adrenergic receptors in rats

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier B.V.
ISSN
0166-4328
D.O.I.
10.1016/j.bbr.2018.02.022
Publisher site
See Article on Publisher Site

Abstract

•Guanfacine improved food-motivated impulsive choices in the delay discounting task.•Stimulation of the α2A-adrenergic receptor was involved in the effect of guanfacine.•A selective noradrenergic neurotoxin did not affect the effect of guanfacine.

Journal

Behavioural Brain ResearchElsevier

Published: Jun 1, 2018

References

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