Synthetic biology—application-oriented cell engineering

Synthetic biology—application-oriented cell engineering Available online at www.sciencedirect.com ScienceDirect Synthetic biology — application-oriented cell engineering 1 1 1,2 Mingqi Xie , Viktor Haellman and Martin Fussenegger Synthetic biology applies engineering principles to biological their extension to more diverse applications or specifica- systems and reprograms living cells to perform novel and tions [3,4]. improved functions. In this review, we first provide an update of common tools and design principles that enable user- Cell engineering tools defined control of mammalian cell activities with Genome editing spatiotemporal precision. Next, we demonstrate some As the natural ability of cells to control their behaviour is examples of how engineered mammalian cells can be encoded at their genetic level, the capability to engineer developed towards biomedical solutions in the context of complex cell functionalities directly relates to our ex- real-world problems. pertise in manipulating endogenous gene networks. In Addresses recent years, the emergent CRISPR/Cas9 technology Department of Biosystems Science and Engineering, ETH Zurich, enabling facile and permanent modification of genomic Mattenstrasse 26, CH-4058 Basel, Switzerland sequences in mammalian cells and animals has brought University of Basel, Faculty of Science, Mattenstrasse 26, CH-4058 the promise of gene editing designer nucleases back Basel, Switzerland into the limelight [3]. Classical designer nucleases, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Biotechnology Elsevier

Synthetic biology—application-oriented cell engineering

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Publisher
Elsevier
Copyright
Copyright © 2016 Elsevier Ltd
ISSN
0958-1669
D.O.I.
10.1016/j.copbio.2016.04.005
Publisher site
See Article on Publisher Site

Abstract

Available online at www.sciencedirect.com ScienceDirect Synthetic biology — application-oriented cell engineering 1 1 1,2 Mingqi Xie , Viktor Haellman and Martin Fussenegger Synthetic biology applies engineering principles to biological their extension to more diverse applications or specifica- systems and reprograms living cells to perform novel and tions [3,4]. improved functions. In this review, we first provide an update of common tools and design principles that enable user- Cell engineering tools defined control of mammalian cell activities with Genome editing spatiotemporal precision. Next, we demonstrate some As the natural ability of cells to control their behaviour is examples of how engineered mammalian cells can be encoded at their genetic level, the capability to engineer developed towards biomedical solutions in the context of complex cell functionalities directly relates to our ex- real-world problems. pertise in manipulating endogenous gene networks. In Addresses recent years, the emergent CRISPR/Cas9 technology Department of Biosystems Science and Engineering, ETH Zurich, enabling facile and permanent modification of genomic Mattenstrasse 26, CH-4058 Basel, Switzerland sequences in mammalian cells and animals has brought University of Basel, Faculty of Science, Mattenstrasse 26, CH-4058 the promise of gene editing designer nucleases back Basel, Switzerland into the limelight [3]. Classical designer nucleases,

Journal

Current Opinion in BiotechnologyElsevier

Published: Aug 1, 2016

References

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