Synthesis, solvatochromism, photochemistry, DNA binding, photocleavage, cytotoxicity and molecular docking studies of a ruthenium(II) complex bearing photoactive subunit

Synthesis, solvatochromism, photochemistry, DNA binding, photocleavage, cytotoxicity and... A Novel [Ru(phen)2(ppym)]2+ complex was synthesized and characterized. The dual emission (Excimer) characteristics observed for ligand ppym. The title complex was restricting firmly to CT DNA by means of intercalation through its ligand ppym, affirmed by various spectroscopic studies. Photo irradiation of the complex cleaves the pBR322 DNA. The cytotoxicity of [Ru(phen)2(ppym)]2+ was tested in Human malignancy cancer cell line (ZR-75-30) by MTT assay with the IC50 of 10 μg/mL. Molecular docking study of [Ru(phen)2(ppym)]2+ reveals intercalative interactions with the DNA. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Photochemistry and Photobiology A: Chemistry Elsevier

Synthesis, solvatochromism, photochemistry, DNA binding, photocleavage, cytotoxicity and molecular docking studies of a ruthenium(II) complex bearing photoactive subunit

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier B.V.
ISSN
1010-6030
eISSN
1873-2666
D.O.I.
10.1016/j.jphotochem.2018.02.001
Publisher site
See Article on Publisher Site

Abstract

A Novel [Ru(phen)2(ppym)]2+ complex was synthesized and characterized. The dual emission (Excimer) characteristics observed for ligand ppym. The title complex was restricting firmly to CT DNA by means of intercalation through its ligand ppym, affirmed by various spectroscopic studies. Photo irradiation of the complex cleaves the pBR322 DNA. The cytotoxicity of [Ru(phen)2(ppym)]2+ was tested in Human malignancy cancer cell line (ZR-75-30) by MTT assay with the IC50 of 10 μg/mL. Molecular docking study of [Ru(phen)2(ppym)]2+ reveals intercalative interactions with the DNA.

Journal

Journal of Photochemistry and Photobiology A: ChemistryElsevier

Published: Apr 1, 2018

References

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