Synthesis of an electronically-tuned minimally interfering alkynyl photo-affinity label to measure small molecule–protein interactions

Synthesis of an electronically-tuned minimally interfering alkynyl photo-affinity label to... We report the synthesis of an electronically-tuned minimally interfering photo-affinity label (MI-PAL), a compact five-carbon tag functionalized with an alkyl diazirine and alkyne handle. MI-PAL is compatible with protein photo-conjugation, click chemistry and mass spectrometry and readily installed to complex molecules for biological target identification. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Tetrahedron Elsevier

Synthesis of an electronically-tuned minimally interfering alkynyl photo-affinity label to measure small molecule–protein interactions

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier Ltd
ISSN
0040-4020
D.O.I.
10.1016/j.tet.2018.03.024
Publisher site
See Article on Publisher Site

Abstract

We report the synthesis of an electronically-tuned minimally interfering photo-affinity label (MI-PAL), a compact five-carbon tag functionalized with an alkyl diazirine and alkyne handle. MI-PAL is compatible with protein photo-conjugation, click chemistry and mass spectrometry and readily installed to complex molecules for biological target identification.

Journal

TetrahedronElsevier

Published: Jun 28, 2018

References

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