New half sandwich arene ruthenium(II) complexes of the type [Ru(arene)Cl(L)] (where arene = benzene and p-cymene, L = thiophene benzhydrazone ligands) have been synthesized from the reactions of the neutral precursor [Ru(arene) (μ-Cl) Cl]2 and the corresponding benzhydrazone ligand. All the complexes were completely characterized by elemental analysis and additionally by IR, UV–Vis, 1H NMR and ESI-MS spectroscopic methods. The solid state structures of the complexes 6 and 7 were determined by single-crystal X-ray diffraction analysis, which exhibit typical pseudo-octahedral geometry around the metal centre. The antiproliferative activity of the complexes was evaluated on cancerous (HeLa, MDA-MB-231, and Hep G2) and noncancerous (NIH3T3) cell lines. In general, complexes containing electron releasing OCH3 substituent have potential anticancer activity than those incorporating H, Cl and Br substituents. Moreover, the p-cymene complexes show more cytotoxicity than benzene derivatives, suggesting that the substituent at arene plays a vital role in the biological activity of the compounds. Further, an apoptotic mechanism of cell death in MDA-MB-231 was confirmed by AO-EB, Hoechst 33258 staining and annexin-V/PI double-staining techniques. In addition, the extent of DNA fragmentation in cancer cells was studied by comet assay.
Journal of Organometallic Chemistry – Elsevier
Published: Mar 15, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera