Carbohydrate Polymers 181 (2018) 1194–1205 Contents lists available at ScienceDirect Carbohydrate Polymers journal homepage: www.elsevier.com/locate/carbpol Synthesis and characterization of hyaluronic acid hydrogels crosslinked using a solvent-free process for potential biomedical applications Eneko Larrañeta , Megan Henry, Nicola J. Irwin, Johann Trotter, Anastasia A. Perminova, Ryan F. Donnelly School of Pharmacy, Queens University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK ARTICLE I NFO ABSTRACT Keywords: Hyaluronic acid (HA) is a natural linear polysaccharide that has been used extensively in the biomedical ﬁeld as Hyaluronic acid it is a biocompatible, biodegradable, nontoxic and non-immunogenic polymer with high water aﬃnity. Besides, Hydrogels the presence of multiple acid and hydroxyl groups in the HA molecule makes it an ideal candidate for chemical Microneedles modiﬁcation. The present paper describes the synthesis and characterization of HA-based hydrogels. For this purpose, aqueous mixtures containing 5% (w/w) of HA and diﬀerent concentrations of Gantrez S97 (GAN) (1, 3 and 5% w/w) were used to prepare HA-based hydrogels. The mixtures were dried and the hydrogels were obtained after heating the solid material at 80 °C for 24 h. GAN is the acid form of an methylvinylether and maleic anhydride copolymer and contains
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